Also known as: 2(1H)-Pyridinone, 6-hydroxy-4,5-dimethyl-, 2(1H)-Pyridinone, 6-hydroxy-3,4-dimethyl-, 6-Hydroxy-4,5-dimethyl-2(1H)-pyridinone, 6-hydroxy-3,4-dimethyl-2-pyridone, EC No.: 283-141-2 (+2 more)
INCI: 2,6-DIHYDROXY-3,4-DIMETHYLPYRIDINE
2,6-Dihydroxy-3,4-Dimethylpyridine (CAS 84540-47-6) is a cosmetic cosmetic ingredient functioning as Hair Dyeing (coupler in oxidative hair dyes). Reported NOAEL =0.017 mg/kg in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: restricted, max 1.0%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 84540-47-6 →
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for 2,6-Dihydroxy-3,4-Dimethylpyridine.
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10 study endpoints found for 2,6-Dihydroxy-3,4-Dimethylpyridine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.017 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.017 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.017 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.017 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =80 mg/kg | oral | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =80 mg/kg | oral | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =80 mg/kg | oral | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =80 mg/kg | oral | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg bw | - | rat | genotoxicity | SCCS_vision_codex |
| NOAEL | =100 mg/kg | oral | rabbit | dermal absorption | SCCS_vision_codex |
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
1 property record from structured ingredient metadata.
Expert safety assessment and concern-level summary for 2,6-Dihydroxy-3,4-Dimethylpyridine.
Public NOAEL study rows linked to 2,6-Dihydroxy-3,4-Dimethylpyridine by CAS number or substance name.
Units vary across source rows: mg/kg, mg/kg bw
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
2,6-Dihydroxy-3,4-Dimethylpyridine has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
2,6-Dihydroxy-3,4-Dimethylpyridine EU regulatory status: restricted. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.
2,6-Dihydroxy-3,4-Dimethylpyridine functions as: Hair Dyeing (coupler in oxidative hair dyes). It is classified as a cosmetic ingredient in our database. CAS number: 84540-47-6.
The NOAEL (No Observed Adverse Effect Level) for 2,6-Dihydroxy-3,4-Dimethylpyridine is =0.017 mg/kg based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
2,6-Dihydroxy-3,4-Dimethylpyridine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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