2,6-Dihydroxy-3,4-Dimethylpyridine
INCI: 2,6-DIHYDROXY-3,4-DIMETHYLPYRIDINE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for 2,6-Dihydroxy-3,4-Dimethylpyridine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 80 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| LOAEL | 160 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
Expert Verdict
Hair dye use only; restricted to oxidative formulations; mixing ratio must be labeled
Regulatory Flags
Frequently Asked Questions
Is 2,6-Dihydroxy-3,4-Dimethylpyridine safe in cosmetics?
Hair dye use only; restricted to oxidative formulations; mixing ratio must be labeled The EU classifies 2,6-Dihydroxy-3,4-Dimethylpyridine as "restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is 2,6-Dihydroxy-3,4-Dimethylpyridine allowed in the EU?
2,6-Dihydroxy-3,4-Dimethylpyridine EU regulatory status: restricted. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,6-Dihydroxy-3,4-Dimethylpyridine do in cosmetics?
2,6-Dihydroxy-3,4-Dimethylpyridine functions as: Hair Dyeing (coupler in oxidative hair dyes). It is classified as a cosmetic ingredient in our database. CAS number: 84540-47-6.
What is the Margin of Safety for 2,6-Dihydroxy-3,4-Dimethylpyridine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 2,6-Dihydroxy-3,4-Dimethylpyridine?
The NOAEL (No Observed Adverse Effect Level) for 2,6-Dihydroxy-3,4-Dimethylpyridine is 80 mg/kg bw/day based on a Developmental study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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