NOAEL Data REACH Registered Cosmetic Ingredient

2,3-Diaminodihydropyrazolo pyrazolone dimethosulfonate

Also known as: UNII-S409QAZ004, 1H,5H-Pyrazolo(1,2-a)pyrazol-1-one, 2,3-diamino-6,7-dihydro-, dimethanesulfonate, Imexine OBH

CAS 857035-95-1

2,3-Diaminodihydropyrazolo pyrazolone dimethosulfonate (CAS 857035-95-1) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS, ECHA REACH.

View cosmetic safety profile for 2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 8 fields

Name

2,3-Diaminodihydropyrazolo pyrazolone dimethosulfonate

CAS Number

857035-95-1

Molecular Formula

C6H10N4O.2CH4O3S

InChI Key

PFGOOGAEVIKREH-UHFFFAOYSA-N

Monoisotopic Mass

346.061691

Synonyms

UNII-S409QAZ0041H,5H-Pyrazolo(1,2-a)pyrazol-1-one, 2,3-diamino-6,7-dihydro-, dimethanesulfonateImexine OBH

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 17 of 17 studies

Value	Unit	Endpoint	Route	Species	Source
300	mg/kg bw/day	-	-	-	Regulatory source
300	mg/kg bw/day	-	oral	rat	Regulatory source
S409QAZ004	UNII	FDA UNII substance identifier	-	-	openFDA substances
=1000	mg/kg bw/day	LEL	oral	Rat	ECHA
=0.03	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=300	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=300	mg/kg bw/day	NOAEL	-	-	SCCS Opinion
=300	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=1000	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=1000	mg/kg bw/day	NOAEL	-	-	SCCS Opinion
=0.03	mg/kg bw/d	dermal absorption	oral	rat	Regulatory source
=300	mg/kg bw/d	dermal absorption	oral	rat	Regulatory source
300	mg/kg bw/day	developmental toxicity	-	rabbit	Regulatory source
1000	mg/kg bw/day	developmental toxicity	-	-	Regulatory source
1000	mg/kg bw/day	developmental toxicity	-	rabbit	Regulatory source
300	mg/kg bw/day	repeated dose toxicity	-	-	Regulatory source
1000	mg/kg bw/day	repeated dose toxicity	-	human	Regulatory source

Showing 17 of 17 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	1H,5H-Pyrazolo(1,2-a)pyrazol-1-one, 2,3-diamino-6,7-dihydro-, dimethanesulfonate	469-500-8	ECHA overview →

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1478/12	18 September 2012	safe	2.0%	sensitisation potential not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Frequently Asked Questions

What is the NOAEL for 2,3-Diaminodihydropyrazolo pyrazolone dimethosulfonate?

2,3-Diaminodihydropyrazolo pyrazolone dimethosulfonate has 17 NOAEL studies in the database. The lowest reported value is 300 mg/kg bw/day. Source: Regulatory source.

What regulatory lists include 2,3-Diaminodihydropyrazolo pyrazolone dimethosulfonate?

2,3-Diaminodihydropyrazolo pyrazolone dimethosulfonate appears on 2 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring. Source: EPA CPDat.

Is 2,3-Diaminodihydropyrazolo pyrazolone dimethosulfonate used in cosmetics?

Yes, 2,3-Diaminodihydropyrazolo pyrazolone dimethosulfonate is also indexed as a cosmetic ingredient under the name 2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2,3-Diaminodihydropyrazolo pyrazolone dimethosulfonate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 2,3-Diaminodihydropyrazolo pyrazolone dimethosulfonate used outside industrial chemicals?

2,3-Diaminodihydropyrazolo pyrazolone dimethosulfonate also appears in cosmetics databases.