Moderate Cosmetic Ingredient NOAEL Data

2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate

INCI: 2,3-DIAMINODIHYDROPYRAZOLO PYRAZOLONE DIMETHOSULFONATE

CAS Number
857035-95-1
Function
Hair dyeing - oxidative hair dye precursor/coupler
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Coal-tar hair dye exemption under FD\&C Act ยง 601(a) - requires caution statement and patch test directions on label

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for 2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 300 mg/kg bw/day oral - - SCCS_Perplexity

Expert Verdict

Aromatic diamine functionality; mandatory patch test labeling; contains two amino groups reactive with hair keratin and potentially with skin proteins

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Concern Level: Moderate

Regulatory Flags

eu_cosing_listed

Frequently Asked Questions

Is 2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate safe in cosmetics?

Aromatic diamine functionality; mandatory patch test labeling; contains two amino groups reactive with hair keratin and potentially with skin proteins The EU classifies 2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate as "restricted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is 2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate allowed in the EU?

2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does 2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate do in cosmetics?

2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate functions as: Hair dyeing - oxidative hair dye precursor/coupler. It is classified as a cosmetic ingredient in our database. CAS number: 857035-95-1.

What is the Margin of Safety for 2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate?

The NOAEL (No Observed Adverse Effect Level) for 2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate is 300 mg/kg bw/day based on a toxicological study via oral route in rat. Source: SCCS_Perplexity.

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