What is the NOAEL for 1-Naphthaleneacetic acid?
1-Naphthaleneacetic acid has 56 NOAEL studies in the database. The lowest reported value is 0.1 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.
NOAEL Data
Cosmetic Ingredient
1-Naphthaleneacetic acid
Also known as: NAA, 2-(1-Naphthyl)acetic acid, 2-(Naphthalen-1-yl)acetic acid, 2-(α-Naphthyl)ethanoic acid, Alphaspra (+14 more)
CAS 86-87-3
1-Naphthaleneacetic acid (CAS 86-87-3) is a chemical substance. Key regulatory status: 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
1-Naphthaleneacetic acid is classified GHS Danger (H302, H315, H318, H319, H335, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
56
SOURCE
chemical inventory jurisdictions
Regulatory lists
60
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
1-Naphthaleneacetic acid
CAS Number
86-87-3
DTXSID
DTXSID8020915
Molecular Formula
C12H10O2
InChI Key
PRPINYUDVPFIRX-UHFFFAOYSA-N
Monoisotopic Mass
186.06808
Synonyms
NAA2-(1-Naphthyl)acetic acid2-(Naphthalen-1-yl)acetic acid2-(α-Naphthyl)ethanoic acidAlphaspraAppl-setCaswell No. 589EINECS 201-705-8EPA Pesticide Chemical Code 056002FloramonFruit FixHormofix
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides | USDA | United States Department of Agriculture (USDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 56 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.1 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.1 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.1 | mg/kg bw | ARfD | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.1 | mg/kg bw | ARfD | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| 1 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 33T7G7757C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 33T7G7757C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 33T7G7757C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 33T7G7757C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >207 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =1000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =10 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =10 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =10 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =15 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =15 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =15 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =0.25 | mg/kg bw/day | PAD (RfD) | oral | Human | ToxValDB_EPA_OPP |
| - | % | Positive reaction | Dermal | Human | NTP_ICE_skin_irritation |
| 88.6 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 90.73 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 91.96 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 92.2 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 92.7 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 93.96 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 94.56 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 95.2 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 96.39 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 97.36 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 97.78 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 97.8 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 98.15 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 98.2 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 98.32 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 98.5 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 98.65 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 99.3 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 101.04 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 101.34 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 101.8 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 102.07 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 102.11 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 102.28 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 103.66 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 103.69 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 103.91 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 103.96 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 104.39 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 105.52 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
Showing 50 of 56 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL428495
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 1-Naphthaleneacetic acid?
1-Naphthaleneacetic acid appears on 5 regulatory/inventory lists including Canada; pharmaceutical, active_ingredient; Europe; Pesticides, active_ingredient; Pesticides, and 2 more. Source: EPA CPDat.
Is 1-Naphthaleneacetic acid used in cosmetics?
Yes, 1-Naphthaleneacetic acid is also indexed as a cosmetic ingredient under the name 1-Naphthaleneacetic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1-Naphthaleneacetic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 1-Naphthaleneacetic acid have different safety status in cosmetics vs industrial chemicals?
1-Naphthaleneacetic acid is classified GHS Danger (H302, H315, H318, H319, H335, H412) in the chemicals database but is allowed in EU cosmetics.
Is 1-Naphthaleneacetic acid used outside industrial chemicals?
1-Naphthaleneacetic acid also appears in cosmetics, pharmaceutical, cannabis databases.