NOAEL Data REACH Registered Cosmetic Ingredient

HC Yellow no. 9

Also known as: UNII-91P0Z9H61V, 1,2-Ethanediamine, N-(5-methoxy-2-nitrophenyl)-, monohydrochloride, 1,2-Ethanediamine, n1-(5-methoxy-2-nitrophenyl)-, hydrochloride (1:1), Ethylenediamine, N-(5-methoxy-2-nitrophenyl)-, hydrochloride, HC Yellow 9 (+1 more)

CAS 86419-69-4

HC Yellow no. 9 (CAS 86419-69-4) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for HC Yellow No. 9 →

Cross-Vertical Regulatory Divergence

HC Yellow no. 9 is classified GHS Danger (H302, H301) in the chemicals database but is restricted in EU cosmetics at max 0.5%.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 11 fields

Name

HC Yellow no. 9

CAS Number

86419-69-4

Molecular Formula

C9H13N3O3.ClH

InChI Key

AFAJYBYVKUTWJK-UHFFFAOYSA-N

Monoisotopic Mass

247.072369

Synonyms

UNII-91P0Z9H61V1,2-Ethanediamine, N-(5-methoxy-2-nitrophenyl)-, monohydrochloride1,2-Ethanediamine, n1-(5-methoxy-2-nitrophenyl)-, hydrochloride (1:1)Ethylenediamine, N-(5-methoxy-2-nitrophenyl)-, hydrochlorideHC Yellow 9Imexine FAD

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Canada; Personal care; Substances in PCP - Canada (4/2014)	Government of Canada	CPCat
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 17 of 17 studies

Value	Unit	Endpoint	Route	Species	Source
250	mg/kg bw/day	-	-	rat	Regulatory source
91P0Z9H61V	UNII	FDA UNII substance identifier	-	-	openFDA substances
=0.09	mg/kg bw	NOAEL	dermal	rat	SCCS Opinion
=70	mg/kg bw/day	NOAEL	oral	mouse	SCCS Opinion
=70	mg/kg bw/d	NOAEL	dermal	rat	SCCS Opinion
=80	mg/kg bw/day	NOAEL	-	rat	SCCS Opinion
=100	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
=250	mg/kg bw/day	NOAEL	-	rat	SCCS Opinion
=250	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=0.09	mg/kg bw	dermal absorption	dermal	rat	Regulatory source
=70	mg/kg bw/d	dermal absorption	dermal	rat	Regulatory source
70	mg/kg bw/day	developmental toxicity	oral	mouse	Regulatory source
80	mg/kg bw/day	genotoxicity	-	rat	Regulatory source
250	mg/kg bw/day	genotoxicity	-	-	Regulatory source
100	mg/kg bw/day	repeated dose toxicity	oral	rat	Regulatory source
250	mg/kg bw/d	repeated dose toxicity	oral	rat	Regulatory source
70	mg/kg bw/d	reproductive toxicity	oral	rat	Regulatory source

Showing 17 of 17 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	1,2-Ethanediamine, N-(5-methoxy-2-nitrophenyl)-, monohydrochloride	415-480-0	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1301/10	22 June 2010	Based on the information provided, the SCCS is of the opinion that the use of HC Yellow n° 9 as a non-oxidative hair dye ingredient at a maximum concentration on the head of 0.5% does not pose a risk to the health of the consumer.	0.5%	A sensitising potential cannot be excluded. It is a secondary amine, prone to nitrosation/nitrosamine formation; should not be used with nitrosating substances; nitrosamine content should be < 50 ppb.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

0.5%

Frequently Asked Questions

What is the NOAEL for HC Yellow no. 9?

HC Yellow no. 9 has 17 NOAEL studies in the database. The lowest reported value is 250 mg/kg bw/day in rat. Source: Regulatory source.

What regulatory lists include HC Yellow no. 9?

HC Yellow no. 9 appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, Canada; Personal care; Substances in PCP - Canada (4/2014), children; Europe; Personal care. Source: EPA CPDat.

Is HC Yellow no. 9 used in cosmetics?

Yes, HC Yellow no. 9 is also indexed as a cosmetic ingredient under the name HC Yellow No. 9. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for HC Yellow no. 9 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does HC Yellow no. 9 have different safety status in cosmetics vs industrial chemicals?

HC Yellow no. 9 is classified GHS Danger (H302, H301) in the chemicals database but is restricted in EU cosmetics at max 0.5%.

Is HC Yellow no. 9 used outside industrial chemicals?

HC Yellow no. 9 also appears in cosmetics databases.