Is HC Yellow No. 9 safe in cosmetics?
HC Yellow No. 9 has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
HC Yellow No. 9
Also known as: UNII-91P0Z9H61V, 1,2-Ethanediamine, N-(5-methoxy-2-nitrophenyl)-, monohydrochloride, 1,2-Ethanediamine, n1-(5-methoxy-2-nitrophenyl)-, hydrochloride (1:1), Ethylenediamine, N-(5-methoxy-2-nitrophenyl)-, hydrochloride, HC Yellow 9 (+1 more)
INCI: HC YELLOW NO. 9
HC Yellow No. 9 (CAS 86419-69-4) is a cosmetic cosmetic ingredient functioning as Hair Dyeing (non-oxidative semi-permanent). Reported NOAEL =0.09 mg/kg bw in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: restricted, max 0.5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 86419-69-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
HC Yellow No. 9 is classified GHS Danger (H302, H301) in the chemicals database but is restricted in EU cosmetics at max 0.5%.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair Dyeing (non-oxidative semi-permanent)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
N'-(5-methoxy-2-nitrophenyl)ethane-1,2-diamine;hydrochloride
InChIKey
AFAJYBYVKUTWJK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.5%
US US Status
permitted
US Notes
Permitted under coal-tar hair dye exemption (FD&C Act §601(a))
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Yellow No. 9.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for HC Yellow No. 9. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.09 mg/kg bw | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.09 mg/kg bw | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.09 mg/kg bw | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.09 mg/kg bw | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =70 mg/kg bw/day | oral | mouse | developmental toxicity | SCCS_vision_codex |
| NOAEL | =70 mg/kg bw/d | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =70 mg/kg bw/day | oral | mouse | developmental toxicity | SCCS_vision_codex |
| NOAEL | =70 mg/kg bw/d | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =70 mg/kg bw/day | oral | mouse | developmental toxicity | SCCS_vision_codex |
| NOAEL | =70 mg/kg bw/d | dermal | rat | dermal absorption | SCCS_vision_codex |
Sensitization Profile
Contact sensitization data for HC Yellow No. 9 based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis
Source: SCCS; IVDK
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products. Max: 0,5% (calculated as hydrochloride).
BRIN Brazil/India Cosmetics
India: Restricted · max 0,5% (calculated as hydrochloride)
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (5 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.4% | - | - | SCCS/0026 |
| measured | 0.08% | - | - | SCCS/0026 |
| measured | 2.8% | - | - | SCCS/0026 |
| measured | 0.21% | - | - | SCCS/0026 |
| measured | 2.94% | - | - | SCCS/0026 |
Additional Ingredient Properties
2 property records from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "dye", "cross_reactivity_group": "para-amino-group", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "SCCS; IVDK"}
hair_dye
{"cas_number": "86419-69-4", "ingredient_class": "direct_dye", "chemical_class": "nitro", "molecular_weight_Da": "299.32", "color_result_on_hair": "Yellow", "shade_range": "blonde", "primary_function": "direct_deposit", "requires_developer": "no", "lift_capability_levels": "0", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-12", "light_fastness": "moderate", "h…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Restricted for Children (Cosmetics)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for HC Yellow No. 9.
Regulatory Flags
eu_children_restricted
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HC Yellow No. 9 by CAS number or substance name.
Studies
28
Lowest NOAEL
0.09
Highest NOAEL
250
Units vary across source rows: mg/kg bw/day, mg/kg bw, mg/kg bw/d
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.4% | - | - |
| 0.08% | - | - |
| 2.8% | - | - |
| 0.21% | - | - |
| 2.94% | - | - |
Known Synonyms
UNII-91P0Z9H61V
1,2-Ethanediamine, N-(5-methoxy-2-nitrophenyl)-, monohydrochloride
1,2-Ethanediamine, n1-(5-methoxy-2-nitrophenyl)-, hydrochloride (1:1)
Ethylenediamine, N-(5-methoxy-2-nitrophenyl)-, hydrochloride
HC Yellow 9
Imexine FAD
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Canada; Personal care; Substances in PCP - Canada (4/2014)
children; Europe; Personal care
children; Europe; Personal care
Australian Status
AICIS status: listed
Frequently Asked Questions
Is HC Yellow No. 9 allowed in the EU?
HC Yellow No. 9 EU regulatory status: restricted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Yellow No. 9 do in cosmetics?
HC Yellow No. 9 functions as: Hair Dyeing (non-oxidative semi-permanent). It is classified as a cosmetic ingredient in our database. CAS number: 86419-69-4.
What is the NOAEL for HC Yellow No. 9?
The NOAEL (No Observed Adverse Effect Level) for HC Yellow No. 9 is =0.09 mg/kg bw based on a dermal absorption study via dermal route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is HC Yellow No. 9 used outside cosmetics?
HC Yellow No. 9 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does HC Yellow No. 9 have different safety status in cosmetics vs industrial chemicals?
HC Yellow No. 9 is classified GHS Danger (H302, H301) in the chemicals database but is restricted in EU cosmetics at max 0.5%.
Compliance Tools
Check HC Yellow No. 9 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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