NOAEL Data REACH Registered Cosmetic Ingredient

4-Chloro-3,5-dimethylphenol

Also known as: 4-Chloro-3,5-xylenol, Chloroxylenol, BRN 1862539, Caswell No. 218, 2-Chloro-m-xylenol (+15 more)

CAS 88-04-0

4-Chloro-3,5-dimethylphenol (CAS 88-04-0) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Chloroxylenol (PCMX) →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

4-Chloro-3,5-dimethylphenol

CAS Number

88-04-0

Molecular Formula

C8H9ClO

InChI Key

OSDLLIBGSJNGJE-UHFFFAOYSA-N

Monoisotopic Mass

156.034193

Synonyms

4-Chloro-3,5-xylenolChloroxylenolBRN 1862539Caswell No. 2182-Chloro-m-xylenolChlorxylenolumDettol, liquid antisepticEINECS 201-793-8EPA Pesticide Chemical Code 086801Husept ExtraNipacide MXOttasept Extra

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 6 records

BiocidePreservativeFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 12 records

List	Keyword	Source
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
pharmaceutical	US International Trade Commission	CPCat
CEDI	FDA	United States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
Europe; Personal care	European Commission	CosIng
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
IFRA Transparency	IFRA	IFRA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 59 studies

Value	Unit	Endpoint	Route	Species	Source
26.58	uM	AC50	-	-	NTP ICE endocrine
19.56	uM	ACC	-	-	NTP ICE endocrine
30	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
4	%	Concentration, one positive response	Dermal	Human	NTP ICE skin sensitization
1	unitless	EPA Classification	Ocular	Rabbit	NTP ICE eye irritation
3	unitless	EPA classification	Dermal	Rat	NTP ICE acute dermal
=3	Unitless	EPA classification	oral	Rat	NTP ICE acute oral
4	unitless	EPA classification	Dermal	Rat	NTP ICE acute dermal
4	unitless	EPA classification	Dermal	Rabbit	NTP ICE skin irritation
0F32U78V2Q	UNII	FDA UNII substance identifier	-	-	openFDA substances
4	unitless	GHS Classification	Inhalation	-	NTP ICE acute inhalation
5	unitless	GHS Classification	Inhalation	-	NTP ICE acute inhalation
5	unitless	GHS classification	Dermal	Rat	NTP ICE acute dermal
=5	Unitless	GHS classification	oral	Rat	NTP ICE acute oral
0	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
3.333	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
3488	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
6975	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
1.395e+4	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
2.250e+4	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
3.375e+4	ug/cm2	Induction dose per skin area, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
4500	ug/cm2	Induction dose per skin area, one positive response	Dermal	Human	NTP ICE skin sensitization
2.26	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
6.29	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
>2000	mg/kg	LD50	Dermal	Rat	NTP ICE acute dermal
=3830	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
>5050	mg/kg	LD50	Dermal	Rat	NTP ICE acute dermal
=213	mg/kg bw/day	LEL	dermal	Mouse	ToxValDB ToxRefDB
=213	mg/kg bw/day	LEL	dermal	mouse (cd1; Crl:CD-1(ICR)BR)	EPA ToxRefDB v3
=284	mg/kg bw/day	LEL	dermal	Mouse	ToxValDB ToxRefDB
=284	mg/kg bw/day	LEL	dermal	mouse (cd1; Crl:CD-1(ICR)BR)	EPA ToxRefDB v3
=300	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=300	mg/kg bw/day	LEL	oral	rat (sprague dawley; Sprague Dawley (CD))	EPA ToxRefDB v3
=500	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=500	mg/kg bw/day	LEL	oral	rat (sprague dawley; Sprague Dawley (CD))	EPA ToxRefDB v3
>1000	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=1250	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=1250	mg/kg bw/day	LEL	oral	rat (sprague dawley; Sprague Dawley)	EPA ToxRefDB v3
=7900	mg/m3	LEL	inhalation	Rat	ECHA
=1000	mg/kg bw/day	LOAEL	oral	rat (sprague dawley; Sprague Dawley (CD))	EPA ToxRefDB v3
=2500	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB ToxRefDB
=2500	mg/kg bw/day	LOAEL	oral	rat (sprague dawley; Sprague Dawley)	EPA ToxRefDB v3
=0.5	mL/kg-day	LOEL	oral	Dog	ToxValDB ECOTOX
=5	mL/kg-day	LOEL	oral	Dog	ToxValDB ECOTOX
=25	%	LOEL	dermal	Mouse	ToxValDB ECOTOX
0	unitless	Model Score	-	-	NTP ICE endocrine
0.0439	unitless	Model Score	-	-	NTP ICE endocrine
>0	mg/kg bw/day	NEL	dermal	mouse (cd1; Crl:CD-1(ICR)BR)	EPA ToxRefDB v3
=25	mg/kg bw/day	NEL	oral	Rat	ToxValDB ToxRefDB
=25	mg/kg bw/day	NEL	oral	rat (sprague dawley; Sprague Dawley)	EPA ToxRefDB v3

Showing 50 of 59 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	4-chloro-3,5-xylenol	201-793-8	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

0.5%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHLOROXYLENOL

ChEMBL Phase

Adverse Events

268

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 4-Chloro-3,5-dimethylphenol?

4-Chloro-3,5-dimethylphenol has 59 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.

What regulatory lists include 4-Chloro-3,5-dimethylphenol?

4-Chloro-3,5-dimethylphenol appears on 8 regulatory/inventory lists including active_ingredient; Pesticides, pharmaceutical, CEDI, and 5 more. Source: EPA CPDat.

Is 4-Chloro-3,5-dimethylphenol used in cosmetics?

Yes, 4-Chloro-3,5-dimethylphenol is also indexed as a cosmetic ingredient under the name Chloroxylenol (PCMX). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-Chloro-3,5-dimethylphenol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 4-Chloro-3,5-dimethylphenol used outside industrial chemicals?

4-Chloro-3,5-dimethylphenol also appears in cosmetics, pharmaceutical databases.