Good Preservative Sensitization Data

Chloroxylenol (PCMX)

INCI: CHLOROXYLENOL

CAS Number
88-04-0
Function
Preservative
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 0.5%
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes CIR Expert Panel 2022 Re-review Summary

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Chloroxylenol (PCMX) based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
preservative
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis

Source: ESSCA; IVDK; NACDG

Expert Verdict

Chloroxylenol is a restricted antimicrobial preservative approved for use in cosmetics with a maximum concentration of 0.5%.

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Concern Level: Moderate

Regulatory Flags

EU Restricted ifra_fragrance eu_cosing_listed

Frequently Asked Questions

Is Chloroxylenol (PCMX) safe in cosmetics?

Chloroxylenol is a restricted antimicrobial preservative approved for use in cosmetics with a maximum concentration of 0.5%. The EU classifies Chloroxylenol (PCMX) as "restricted". Safety rating: GOOD.

Is Chloroxylenol (PCMX) allowed in the EU?

Chloroxylenol (PCMX) EU regulatory status: restricted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.

What does Chloroxylenol (PCMX) do in cosmetics?

Chloroxylenol (PCMX) functions as: Preservative. It is classified as a Preservative in our database. CAS number: 88-04-0.

What is the Margin of Safety for Chloroxylenol (PCMX)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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