NOAEL Data REACH Registered Cosmetic Ingredient

2-Ethylbutyric acid

Also known as: 4-02-00-00950, Acetic acid, diethyl-, BRN 1098634, Diethylacetic acid, EINECS 201-796-4 (+10 more)

CAS 88-09-5

2-Ethylbutyric acid (CAS 88-09-5) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for 2-Ethylbutyric Acid →

Cross-Vertical Regulatory Divergence

2-Ethylbutyric acid is classified GHS Danger (H311, H319, H227, H318, H361, H402) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 21 fields

Name

2-Ethylbutyric acid

CAS Number

88-09-5

DTXSID

DTXSID2041418

Molecular Formula

C6H12O2

InChI Key

OXQGTIUCKGYOAA-UHFFFAOYSA-N

Monoisotopic Mass

116.08373

Synonyms

4-02-00-00950Acetic acid, diethyl-BRN 1098634Diethylacetic acidEINECS 201-796-42-Ethyl butanoic acid2-Ethylbutanoic acidalpha-Ethylbutyric acidalpha-Ethylbuytyric acidFEMA No. 2429NSC 117653-Pentanecarboxylic acid

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records

FragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 30 of 30 studies

Value	Unit	Endpoint	Route	Species	Source
IDY8B990KE	UNII	FDA UNII substance identifier	-	-	openFDA substances
IDY8B990KE	UNII	FDA UNII substance identifier	-	-	openFDA substances
IDY8B990KE	UNII	FDA UNII substance identifier	-	-	openFDA substances
IDY8B990KE	UNII	FDA UNII substance identifier	-	-	openFDA substances
=2200	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
150	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=10	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=50	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=50	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=50	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=125	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=125	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
150	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=200	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=200	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>219	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>219	mg/kg bw/day	NOAEL	oral: unspecified	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=250	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=300	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>300	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>300	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
310	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=340	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=340	mg/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>1000	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>1450	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>1450	mg/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>2500	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>2500	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx

Showing 30 of 30 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2-ethylbutyric acid	201-796-4	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL184290

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 2-Ethylbutyric acid?

2-Ethylbutyric acid has 30 NOAEL studies in the database. The lowest reported value is IDY8B990KE UNII. Source: openFDA substances.

What regulatory lists include 2-Ethylbutyric acid?

2-Ethylbutyric acid appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.

Is 2-Ethylbutyric acid used in cosmetics?

Yes, 2-Ethylbutyric acid is also indexed as a cosmetic ingredient under the name 2-Ethylbutyric Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Ethylbutyric acid come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Ethylbutyric acid have different safety status in cosmetics vs industrial chemicals?

2-Ethylbutyric acid is classified GHS Danger (H311, H319, H227, H318, H361, H402) in the chemicals database but is allowed in EU cosmetics.

Is 2-Ethylbutyric acid used outside industrial chemicals?

2-Ethylbutyric acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.