Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for 2-Ethylbutyric Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 310 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 150 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| LOAEL | 150 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 310 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 10 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 300 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Acidic fragrance ingredient with GRAS status; may cause skin/eye irritation at high concentrations; naturally found in foods including tobacco and Pelargonium graveolens.
Regulatory Flags
Frequently Asked Questions
Is 2-Ethylbutyric Acid safe in cosmetics?
Acidic fragrance ingredient with GRAS status; may cause skin/eye irritation at high concentrations; naturally found in foods including tobacco and Pelargonium graveolens. The EU classifies 2-Ethylbutyric Acid as "permitted". Safety rating: GOOD. 6 toxicological study endpoint(s) are available in our database.
Is 2-Ethylbutyric Acid allowed in the EU?
2-Ethylbutyric Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Ethylbutyric Acid do in cosmetics?
2-Ethylbutyric Acid functions as: Perfuming (acidic odor type). It is classified as a cosmetic ingredient in our database. CAS number: 88-09-5.
What is the Margin of Safety for 2-Ethylbutyric Acid?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 2-Ethylbutyric Acid?
The NOAEL (No Observed Adverse Effect Level) for 2-Ethylbutyric Acid is 310 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 6 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check 2-Ethylbutyric Acid compliance across multiple jurisdictions:
Related Ingredients
Is 2-Ethylbutyric Acid in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 2-Ethylbutyric Acid in your formulation.