Also known as: 1-Vinyl-2-pyrrolidone, N-Vinyl-2-pyrrolidone, 2-Pyrrolidinone, 1-ethenyl-, BRN 0110513, EINECS 201-800-4 (+8 more)
CAS 88-12-0
Vinylpyrrolidone (CAS 88-12-0) is a chemical substance with GHS signal word Danger; key hazard signal: H351; H332; H312; H302; H335; H373 **; H318. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC.
Vinylpyrrolidone is classified GHS Danger (H351, H332, H312, H302, H335, H373, H318) in the chemicals database but is restricted in EU cosmetics at max II/1113 CMR2.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | 19, Sup 7, 71 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Carc. 2; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; STOT RE 2 *; Eye Dam. 1 | H351; H332; H312; H302; H335; H373 **; H318 | ?; ?; GHS08; GHS07; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is corrosive to the eyes. The substance is irritating to the respiratory tract. |
| Long-term Effects | The substance may have effects on the liver. This may result in liver impairment. Tumours have been detected in experimental animals but may not be relevant to humans. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| - | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =0.3 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =0.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 76H9G81541 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 76H9G81541 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 76H9G81541 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 76H9G81541 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.953 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| 2.87 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 3.07 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 3.2 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 3.32 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =4.56 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
| =60 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
Showing 17 of 17 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1-vinyl-2-pyrrolidone | 201-800-4 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Vinylpyrrolidone (CAS 88-12-0) is classified under EU CLP Annex VI as Carc. 2; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; STOT RE 2 *; Eye Dam. 1 with signal word Danger. Hazard statements: H351; H332; H312; H302; H335; H373 **; H318. Source: EU CLP Annex VI (ECHA).
Vinylpyrrolidone has 17 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
Vinylpyrrolidone appears on 4 regulatory/inventory lists including banned; Europe; Personal care, inert_ingredient; non_food_use; Pesticides, drinking_water; Europe; manufacturing; plastic_additive, and 1 more. Source: EPA CPDat.
Vinylpyrrolidone is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, Vinylpyrrolidone is also indexed as a cosmetic ingredient under the name N-VINYL PYRROLIDONE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Vinylpyrrolidone is classified GHS Danger (H351, H332, H312, H302, H335, H373, H318) in the chemicals database but is restricted in EU cosmetics at max II/1113 CMR2.
Vinylpyrrolidone also appears in cosmetics, pharmaceutical databases.