Moderate Cosmetic Ingredient NOAEL Data GHS Classified

N-VINYL PYRROLIDONE

CAS Number
88-12-0
Function
Not Reported
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status Restricted
EU Max Conc. II/1113 CMR2
🇺🇸 US Status allowed
US Notes Allowed. PVP is cleared for multiple uses including cosmetics. VP/VA Copolymer is used at concentrations up to 9–10% in hair sprays.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

6 study endpoints found for N-VINYL PYRROLIDONE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1 mg/kg bw/day oral rat oral REACH
LOAEL 40 mg/kg bw/day oral rat oral REACH
NOAEL 0.0052 2100 1995 rat inhalation REACH
NOAEL ca.5.5 mg/kg bw/day oral rat oral REACH
LOAEL ca.12 mg/kg bw/day oral rat oral REACH
NOAEL 0.075 mg/kg bw/day 1991 rat inhalation REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is corrosive to the eyes. The substance is irritating to the respiratory tract.
Long-term Exposure Effects
The substance may have effects on the liver. This may result in liver impairment. Tumours have been detected in experimental animals but may not be relevant to humans.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Expert Verdict

N-VINYL PYRROLIDONE is listed in the EU CosIng database with functions: Not Reported It is restricted under EU Cosmetics Regulation. Restriction: II/1113 CMR2.

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Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted needs-enrichment eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is N-VINYL PYRROLIDONE safe in cosmetics?

N-VINYL PYRROLIDONE is listed in the EU CosIng database with functions: Not Reported It is restricted under EU Cosmetics Regulation. Restriction: II/1113 CMR2. The EU classifies N-VINYL PYRROLIDONE as "Restricted". Safety rating: MODERATE. 6 toxicological study endpoint(s) are available in our database.

Is N-VINYL PYRROLIDONE allowed in the EU?

N-VINYL PYRROLIDONE EU regulatory status: Restricted. Maximum allowed concentration: II/1113 CMR2. This is based on EU Regulation 1223/2009 and its amendments.

What does N-VINYL PYRROLIDONE do in cosmetics?

N-VINYL PYRROLIDONE functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 88-12-0.

What is the NOAEL for N-VINYL PYRROLIDONE?

The NOAEL (No Observed Adverse Effect Level) for N-VINYL PYRROLIDONE is 1 mg/kg bw/day based on a oral study via oral route in rat. A total of 6 study endpoints are available. Source: REACH.

Compliance Tools

Check N-VINYL PYRROLIDONE compliance across multiple jurisdictions:

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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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