Is N-VINYL PYRROLIDONE safe in cosmetics?
N-VINYL PYRROLIDONE has a safety rating of "MODERATE" in our database. EU status: restricted. US status: allowed.
N-VINYL PYRROLIDONE
Also known as: 1-Vinyl-2-pyrrolidone, N-Vinyl-2-pyrrolidone, 2-Pyrrolidinone, 1-ethenyl-, BRN 0110513, EINECS 201-800-4 (+8 more)
N-VINYL PYRROLIDONE (CAS 88-12-0) is a cosmetic cosmetic ingredient functioning as Not Reported. NOAEL 1 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max II/1113 CMR2. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 88-12-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
N-VINYL PYRROLIDONE is classified GHS Danger (H302, H312, H318, H332, H335, H351, H373, H311) in the chemicals database but is restricted in EU cosmetics at max II/1113 CMR2.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Not Reported
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-ethenylpyrrolidin-2-one
InChIKey
WHNWPMSKXPGLAX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
II/1113
CMR2
US US Status
allowed
US Notes
Allowed. PVP is cleared for multiple uses including cosmetics. VP/VA Copolymer is used at concentrations up to 9–10% in hair sprays.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is corrosive to the eyes. The substance is irritating to the respiratory tract.
Long-term Exposure Effects
The substance may have effects on the liver. This may result in liver impairment. Tumours have been detected in experimental animals but may not be relevant to humans.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for N-VINYL PYRROLIDONE across SCCS product categories, with measured dermal absorption where available.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
19, Sup 7, 71
Evaluation Year
1998
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
?Health HazardHarmful / IrritantCorrosive
Hazard Class and Category
Carc. 2; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; STOT RE 2 *; Eye Dam. 1
Hazard Statements
- H351 Suspected of causing cancer
- H332 Harmful if inhaled
- H312 Harmful in contact with skin
- H302 Harmful if swallowed
- H335 May cause respiratory irritation
- H373 **
- H318 Causes serious eye damage
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1113
(EC) 2009/1223
CMR: Carcinogenic Cat. 2()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Carcinogen Classification
N-Vinyl-2-pyrrolidone | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 19: (1979) Some Monomers, Plastics and Synthetic Elastomers, and Acrolein | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and H
Source: International Agency for Research on Cancer (IARC)
Evidence for Carcinogenicity
Evaluation: No epidemiological data relevant to the carcinogenicity of N-vinyl-2-pyrrolidone ... were available. There is limited evidence for the carcinogenicity of N-vinyl-2-pyrrolidone in experimental animals. Overall evaluation N-Vinyl-2-pyrrolidone is not classifiable as to its carcinogenicity to humans (Group 3). | A3; Confirmed animal carcinogen with unknown relevance to humans.
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
1478
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Solvent
Regulatory List Membership (3)
EU Banned in Cosmetics
FDA Indirect Food Contact Additives
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for N-VINYL PYRROLIDONE.
Regulatory Flags
cosing-sourced
eu-restricted
needs-enrichment
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
1-Vinyl-2-pyrrolidone
N-Vinyl-2-pyrrolidone
2-Pyrrolidinone, 1-ethenyl-
BRN 0110513
EINECS 201-800-4
Vinylpyrrolidinone
N-Vinylpyrrolidinone
1-Vinylpyrrolidinone
1-Vinyl-2-pyrrolidinone, monomer
N-Vinylpyrrolidone
1-Vinylpyrrolidone
Vinyl-2-pyrrolidone
UNII-76H9G81541
Chemical Function
Solvent
No specific technical function
Regulatory Lists
banned; Europe; Personal care
inert_ingredient; non_food_use; Pesticides
drinking_water; Europe; manufacturing; plastic_additive
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. These obligations are: 1. If the assessment report about the chemical recommends secondary notification of the chemical in particular circumstances and any of the circumstances occur in relation to the introduction (importation or manufacture) of the chemical by a person, then the...
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1878943
Frequently Asked Questions
Is N-VINYL PYRROLIDONE allowed in the EU?
N-VINYL PYRROLIDONE EU regulatory status: restricted. Maximum allowed concentration: II/1113 CMR2. This is based on EU Regulation 1223/2009 and its amendments.
What does N-VINYL PYRROLIDONE do in cosmetics?
N-VINYL PYRROLIDONE functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 88-12-0.
Is N-VINYL PYRROLIDONE used outside cosmetics?
N-VINYL PYRROLIDONE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does N-VINYL PYRROLIDONE have different safety status in cosmetics vs industrial chemicals?
N-VINYL PYRROLIDONE is classified GHS Danger (H302, H312, H318, H332, H335, H351, H373, H311) in the chemicals database but is restricted in EU cosmetics at max II/1113 CMR2.
Compliance Tools
Check N-VINYL PYRROLIDONE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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