What is the NOAEL for 2,5-Di-tert-butylbenzene-1,4-diol?
2,5-Di-tert-butylbenzene-1,4-diol has 12 NOAEL studies in the database. The lowest reported value is 0.822 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,5-Di-tert-butylbenzene-1,4-diol
Also known as: 1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)-, 2,5-Di-tert-butylhydroquinone, Antage DBH, BRN 2049542, 2,5-Di-t-butylhydroquinone (+15 more)
CAS 88-58-4
2,5-Di-tert-butylbenzene-1,4-diol (CAS 88-58-4) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
2,5-Di-tert-butylbenzene-1,4-diol is classified GHS Danger (H301, H302, H315, H317, H319, H335, H373, H400) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
26 fields
Name
2,5-Di-tert-butylbenzene-1,4-diol
CAS Number
88-58-4
DTXSID
DTXSID8041248
Molecular Formula
C14H22O2
InChI Key
JZODKRWQWUWGCD-UHFFFAOYSA-N
Monoisotopic Mass
222.16198
Synonyms
1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)-2,5-Di-tert-butylhydroquinoneAntage DBHBRN 20495422,5-Di-t-butylhydroquinoneEINECS 201-841-8Naugard 451Nocrac NS 7NSC 11Santovar O2,5-Di-tert-butyl-1,4-hydroquinone2,5-Di-tert-butyl-1,4-benzohydroquinone
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
8 records
AntioxidantBiocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 34.8079919974549 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 39.5813543500983 | uM | ACC | - | - | NTP_ICE_endocrine |
| 117 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =0.822 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 26XK13B61B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 26XK13B61B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 26XK13B61B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 26XK13B61B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1.83e-7 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0413 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,5-di-tert-butylhydroquinone | 201-841-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL480626
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
4
Frequently Asked Questions
What regulatory lists include 2,5-Di-tert-butylbenzene-1,4-diol?
2,5-Di-tert-butylbenzene-1,4-diol appears on 1 regulatory/inventory list including Indirect additives food contact (10/2018). Source: EPA CPDat.
Is 2,5-Di-tert-butylbenzene-1,4-diol used in cosmetics?
Yes, 2,5-Di-tert-butylbenzene-1,4-diol is also indexed as a cosmetic ingredient under the name DI-T-BUTYLHYDROQUINONE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,5-Di-tert-butylbenzene-1,4-diol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2,5-Di-tert-butylbenzene-1,4-diol have different safety status in cosmetics vs industrial chemicals?
2,5-Di-tert-butylbenzene-1,4-diol is classified GHS Danger (H301, H302, H315, H317, H319, H335, H373, H400) in the chemicals database but is allowed in EU cosmetics.
Is 2,5-Di-tert-butylbenzene-1,4-diol used outside industrial chemicals?
2,5-Di-tert-butylbenzene-1,4-diol also appears in cosmetics, pharmaceutical databases.