Also known as: 1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)-, 2,5-Di-tert-butylhydroquinone, Antage DBH, BRN 2049542, 2,5-Di-t-butylhydroquinone (+15 more)
DI-T-BUTYLHYDROQUINONE (CAS 88-58-4) is a cosmetic cosmetic ingredient functioning as Antioxidant. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; 1 safety opinion reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
DI-T-BUTYLHYDROQUINONE is classified GHS Danger (H301, H302, H315, H317, H319, H335, H373, H400) in the chemicals database but is allowed in EU cosmetics.
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Toxicological Studies
1 study endpoint found for DI-T-BUTYLHYDROQUINONE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=50 mg/kg bw/day
oral
Rat
short-term
ECHA
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
CIR Safety AssessmentPhiladelphia
0 1996
Verdict: unknown
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for DI-T-BUTYLHYDROQUINONE across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
AntioxidantBiocide
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Editorial summary
Preliminary editorial summary for DI-T-BUTYLHYDROQUINONE — not a computed safety verdict. See the sourced toxicological data above.
DI-T-BUTYLHYDROQUINONE has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
Is DI-T-BUTYLHYDROQUINONE allowed in the EU?
DI-T-BUTYLHYDROQUINONE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does DI-T-BUTYLHYDROQUINONE do in cosmetics?
DI-T-BUTYLHYDROQUINONE functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 88-58-4.
What is the NOAEL for DI-T-BUTYLHYDROQUINONE?
The NOAEL (No Observed Adverse Effect Level) for DI-T-BUTYLHYDROQUINONE is =50 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ECHA.
Is DI-T-BUTYLHYDROQUINONE used outside cosmetics?
DI-T-BUTYLHYDROQUINONE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does DI-T-BUTYLHYDROQUINONE have different safety status in cosmetics vs industrial chemicals?
DI-T-BUTYLHYDROQUINONE is classified GHS Danger (H301, H302, H315, H317, H319, H335, H373, H400) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check DI-T-BUTYLHYDROQUINONE compliance across multiple jurisdictions:
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