Is DI-T-BUTYLHYDROQUINONE safe in cosmetics?
DI-T-BUTYLHYDROQUINONE has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
DI-T-BUTYLHYDROQUINONE
Also known as: 1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)-, 2,5-Di-tert-butylhydroquinone, Antage DBH, BRN 2049542, 2,5-Di-t-butylhydroquinone (+15 more)
DI-T-BUTYLHYDROQUINONE (CAS 88-58-4) is a cosmetic cosmetic ingredient functioning as Antioxidant. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 88-58-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
DI-T-BUTYLHYDROQUINONE is classified GHS Danger (H301, H302, H315, H317, H319, H335, H373, H400) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2,5-ditert-butylbenzene-1,4-diol
InChIKey
JZODKRWQWUWGCD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for DI-T-BUTYLHYDROQUINONE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
Philadelphia
0 1996
Verdict: unknown
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for DI-T-BUTYLHYDROQUINONE across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Biocide
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for DI-T-BUTYLHYDROQUINONE.
Regulatory Flags
cosing-sourced
eu-permitted
antioxidant
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to DI-T-BUTYLHYDROQUINONE by CAS number or substance name.
Studies
1
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
50 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)-
2,5-Di-tert-butylhydroquinone
Antage DBH
BRN 2049542
2,5-Di-t-butylhydroquinone
EINECS 201-841-8
Naugard 451
Nocrac NS 7
NSC 11
Santovar O
2,5-Di-tert-butyl-1,4-hydroquinone
2,5-Di-tert-butyl-1,4-benzohydroquinone
2,5-Di-tert-butyl-1,4-benzenediol
1,4-Dihydroxy-2,5-di-tert-butylbenzene
Hydrpquinone, 2,5-di-tert-butyl-
2,5-Di-tert-butylquinol
Nonflex Alba
UNII-26XK13B61B
2,5-TBHQ
2,5-di-tert--butyl-hydroquinone
Chemical Function
Antioxidant
Biocide
Regulatory Lists
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL480626
Frequently Asked Questions
Is DI-T-BUTYLHYDROQUINONE allowed in the EU?
DI-T-BUTYLHYDROQUINONE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does DI-T-BUTYLHYDROQUINONE do in cosmetics?
DI-T-BUTYLHYDROQUINONE functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 88-58-4.
What is the NOAEL for DI-T-BUTYLHYDROQUINONE?
The NOAEL (No Observed Adverse Effect Level) for DI-T-BUTYLHYDROQUINONE is =50 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is DI-T-BUTYLHYDROQUINONE used outside cosmetics?
DI-T-BUTYLHYDROQUINONE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does DI-T-BUTYLHYDROQUINONE have different safety status in cosmetics vs industrial chemicals?
DI-T-BUTYLHYDROQUINONE is classified GHS Danger (H301, H302, H315, H317, H319, H335, H373, H400) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check DI-T-BUTYLHYDROQUINONE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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