What is the NOAEL for Dl-Menthyl acetate?
Dl-Menthyl acetate has 11 NOAEL studies in the database. The lowest reported value is 33.6 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dl-Menthyl acetate
Also known as: Menthol, acetate, cis-1,3,trans-1,4-, Cyclohexanol, 5-methyl-2-(1-methylethyl)-, acetate, (1R,2S,5R)-rel-, Cyclohexanol, 5-methyl-2-(1-methylethyl)-, acetate, (1α,2β,5α)-, (+/-)-Menthol acetate, (+/-)-Menthyl acetate (+8 more)
CAS 89-48-5
Dl-Menthyl acetate (CAS 89-48-5) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Dl-Menthyl acetate
CAS Number
89-48-5
DTXSID
DTXSID9041817
Molecular Formula
C12H22O2
InChI Key
XHXUANMFYXWVNG-GMUICDJXNA-N
Monoisotopic Mass
198.16198
Synonyms
Menthol, acetate, cis-1,3,trans-1,4-Cyclohexanol, 5-methyl-2-(1-methylethyl)-, acetate, (1R,2S,5R)-rel-Cyclohexanol, 5-methyl-2-(1-methylethyl)-, acetate, (1α,2β,5α)-(+/-)-Menthol acetate(+/-)-Menthyl acetateCyclohexanol, 5-methyl-2-(1-methylethyl)-, 1-acetate, (1R,2S,5R)-rel-EC No.: 201-911-8EINECS 201-911-8p-Menth-3-yl acetate, dl-UNII-LF3LEI45OHMenthyl acetaterel-(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl acetate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
7 records
DeodorizerFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =33.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| LF3LEI45OH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| LF3LEI45OH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| LF3LEI45OH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| LF3LEI45OH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =375 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =375 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =375 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =600 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_EFSA |
| =600 | mg/kg bw/day | NOAEL | oral: feed | Mouse | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =600 | mg/kg bw/day | NOAEL | oral: feed | Mouse | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Menthyl acetate | 201-911-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Dl-Menthyl acetate?
Dl-Menthyl acetate appears on 4 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, IFRA Transparency, Europe, and 1 more. Source: EPA CPDat.
Is Dl-Menthyl acetate used in cosmetics?
Yes, Dl-Menthyl acetate is also indexed as a cosmetic ingredient under the name Menthyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dl-Menthyl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Dl-Menthyl acetate used outside industrial chemicals?
Dl-Menthyl acetate also appears in cosmetics, cannabis databases.