Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Menthyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >7500 ppm | oral | rat | oral | REACH |
| NOAEL | >4000 ppm | oral | mouse | oral | REACH |
| NOAEL | >15000 ppm | oral | rat | oral | REACH |
| NOAEL | 7500 ppm | oral | mouse | oral | REACH |
| NOAEL | >7500 ppm | oral | rat | oral | REACH |
| NOAEL | >4000 ppm | oral | mouse | oral | REACH |
| NOAEL | >15000 ppm | oral | rat | oral | REACH |
| NOAEL | 7500 ppm | oral | mouse | oral | REACH |
Expert Verdict
Low concern. RIFM read-across data show no genotoxicity or skin sensitization potential; the chemical structure is not expected to react with skin proteins. Naturally present in peppermint essential oil at 2-10%; provides a characteristic minty-fresh cooling sensation; synthetic and plant-derived grades available
Regulatory Flags
Frequently Asked Questions
Is Menthyl Acetate safe in cosmetics?
Low concern. RIFM read-across data show no genotoxicity or skin sensitization potential; the chemical structure is not expected to react with skin proteins. Naturally present in peppermint essential oil at 2-10%; provides a characteristic minty-fresh cooling sensation; synthetic and plant-derived grades available The EU classifies Menthyl Acetate as "permitted". Safety rating: MODERATE. 8 toxicological study endpoint(s) are available in our database.
Is Menthyl Acetate allowed in the EU?
Menthyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Menthyl Acetate do in cosmetics?
Menthyl Acetate functions as: Fragrance, Refreshing. It is classified as a cosmetic ingredient in our database. CAS number: 89-48-5.
What is the Margin of Safety for Menthyl Acetate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Menthyl Acetate?
The NOAEL (No Observed Adverse Effect Level) for Menthyl Acetate is >7500 ppm based on a oral study via oral route in rat. A total of 8 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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