What is the NOAEL for Polyoxyethylene dodecyl mono ether?
Polyoxyethylene dodecyl mono ether has 39 NOAEL studies in the database. The lowest reported value is 0 unitless via Ocular in Rabbit. Source: NTP ICE eye irritation.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Polyoxyethylene dodecyl mono ether
Also known as: alpha-Dodecyl-omega-hydroxypoly(oxyethylene), Polyoxyethylene lauryl ether, Dodecyl poly(oxyethylene) ether, Poly(oxy-1,2-ethanediyl), alpha-dodecyl-omega-hydroxy-, EC No.: 500-002-6 (+14 more)
CAS 9002-92-0
Polyoxyethylene dodecyl mono ether (CAS 9002-92-0) is a chemical substance. Key regulatory status: REACH registered, 16 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Polyoxyethylene dodecyl mono ether is classified GHS Danger (H302, H315, H318, H319, H400, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
39
SOURCE
Chemical inventory jurisdictions
Regulatory lists
16
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
Polyoxyethylene dodecyl mono ether
CAS Number
9002-92-0
Synonyms
alpha-Dodecyl-omega-hydroxypoly(oxyethylene)Polyoxyethylene lauryl etherDodecyl poly(oxyethylene) etherPoly(oxy-1,2-ethanediyl), alpha-dodecyl-omega-hydroxy-EC No.: 500-002-6Dodecyl alcohol, ethoxylatedPoly(oxy-1,2-ethanediyl), .alpha.-dodecyl-.omega.-hydroxy-Ethoxylated dodecyl alcoholAtlas G-2133Atlas G-3705Dodecanol, ethoxylateNoniolite AL 20
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Surfactant (surface active agent)Anti-static agentDeodorizerEmulsifierCleaning agentDegradant/impurityNo specific technical functionFragranceHeat stabilizerDispersing agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
16 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| IFRA Transparency | IFRA | IFRA |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | US International Trade Commission | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 39 of 39 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 300 | mg/kg | - | - | - | Regulatory source |
| <1200 | mg/kg bw | - | dermal | rat | Regulatory source |
| 4000 | mg/kg | - | dermal | rabbit | Regulatory source |
| =4.93 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 0 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP ICE eye irritation |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP ICE eye irritation |
| 002FR4N8OV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0AWH8BFG9A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6HQ855798J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6SU0SC83AH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| APG12V4K45 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BD7AST04GA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ELB3Y6474W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| KZF7XN8153 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| MGU0HEW21Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N72LMW566G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OAH19558U1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QU7U88D04I | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RPD53041LR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W9D845551A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WG3R46N0SV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z95S6G8201 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.01 | %/sec | Intensity | Ocular | - | NTP ICE eye irritation |
| >=1 | mg/kg bw/day | LEL | injection | Dog | ECHA |
| >=3 | mg/kg bw/day | LEL | injection | Dog | ECHA |
| >=6 | mg/kg bw/day | LEL | injection | Dog | ECHA |
| =9 | mg/kg bw/day | LEL | injection | Rat | ECHA |
| =12 | mg/kg bw/day | LEL | injection | Dog | ECHA |
| =14 | mg/kg bw/day | LEL | injection | Rat | ECHA |
| =300 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| =700 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| >180 | s | Lag time | Ocular | - | NTP ICE eye irritation |
| =0 | ppm | NOAEL | oral | rat | CIR Safety Assessment |
| =0.1 | % | NOAEL | oral | rat | CIR Safety Assessment |
| =0.375 | % | NOAEL | oral | rat | CIR Safety Assessment |
| >0.5 | % | NOAEL | oral | rat | CIR Safety Assessment |
| =1 | mg/kg bw/day | NOAEL | injection | Rat | ECHA |
| =1 | mg/kg bw/day | NOAEL | intravenous | dog (Beagle; male/female) | FDA |
| =1 | % | NOAEL | oral | rat | CIR Safety Assessment |
Showing 39 of 39 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dodecan-1-ol, ethoxylated | 500-002-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/1130/07 | 2 October 2007 | safe with restrictions | 3% leave-on; 4% rinse-off (addendum confirms) | Surfactant; skin irritation at high concentrations; low sensitisation potential |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
polidocanol
ChEMBL Phase
Not listed
Adverse Events
59
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Polyoxyethylene dodecyl mono ether?
Polyoxyethylene dodecyl mono ether appears on 13 regulatory/inventory lists including active_ingredient; Pesticides, SCIL (9/2019), Europe; Specialty occupational products, and 10 more. Source: EPA CPDat.
Is Polyoxyethylene dodecyl mono ether used in cosmetics?
Yes, Polyoxyethylene dodecyl mono ether is also indexed as a cosmetic ingredient under the name Laureth-50. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Polyoxyethylene dodecyl mono ether come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Polyoxyethylene dodecyl mono ether have different safety status in cosmetics vs industrial chemicals?
Polyoxyethylene dodecyl mono ether is classified GHS Danger (H302, H315, H318, H319, H400, H412) in the chemicals database but is allowed in EU cosmetics.
Is Polyoxyethylene dodecyl mono ether used outside industrial chemicals?
Polyoxyethylene dodecyl mono ether also appears in cosmetics, pharmaceutical databases.