Is Laureth-50 safe in cosmetics?
Laureth-50 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Laureth-50
Also known as: alpha-Dodecyl-omega-hydroxypoly(oxyethylene), Polyoxyethylene lauryl ether, Dodecyl poly(oxyethylene) ether, Poly(oxy-1,2-ethanediyl), alpha-dodecyl-omega-hydroxy-, EC No.: 500-002-6 (+14 more)
INCI: LAURETH-50
Laureth-50 (CAS 9002-92-0) is a cosmetic cosmetic ingredient functioning as Surfactant – emulsifying agent, surfactant – cleansing, fragrance functional. NOAEL 100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; 5 safety opinions reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 9002-92-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Laureth-50 is classified GHS Danger (H302, H315, H318, H319, H400, H412) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Surfactant – emulsifying agent, surfactant – cleansing, fragrance functional
Safety Rating
GOOD
Chemistry & Identifiers
EC Number
500-002-6
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted – no specific CFR restriction; CIR-reviewed safe when formulated to be non-irritating
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Laureth-50.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Laureth-50. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =7 mg/kg | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =7 mg/kg | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =7 mg/kg | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =7 mg/kg | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =190 mg/kg | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =190 mg/kg | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =190 mg/kg | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =190 mg/kg | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =300 mg/kg | - | - | NOAEL study | CIR_vision_codex |
| NOAEL | =300 mg/kg | - | - | NOAEL study | CIR_vision_codex |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
Verdict: safe
NOAEL: 1.6 g/kg (oral)
polated from the existing data to support safety. The Panel concluded that the Alkyl PEG ethers are safe as used when formulated to be nonirritating, and the same applies to future alkyl PEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol
cir
Verdict: safe
NOAEL: 400 mg/kg (not specified)
polated from the existing data to support safety. The Panel concluded that the Alkyl PEG ethers are safe as used when formulated to be nonirritating, and the same applies to future alkyl PEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol
cir
Verdict: safe
NOAEL: 1200 mg/kg (not specified)
polated from the existing data to support safety. The Panel concluded that the Alkyl PEG ethers are safe as used when formulated to be nonirritating, and the same applies to future alkyl PEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol
cir
Verdict: safe
NOAEL: 4000 mg/kg (dermal)
polated from the existing data to support safety. The Panel concluded that the Alkyl PEG ethers are safe as used when formulated to be nonirritating, and the same applies to future alkyl PEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol
cir
Verdict: safe
NOAEL: 1650 mg/kg bw (not specified)
polated from the existing data to support safety. The Panel concluded that the Alkyl PEG ethers are safe as used when formulated to be nonirritating, and the same applies to future alkyl PEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Laureth-50 across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Cleaning agent
Degradant/impurity
Deodorizer
Dispersing agent
Emulsifier
Fragrance
Heat stabilizer
Humectant
No specific technical function
Regulatory List Membership (4)
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Laureth-50.
Regulatory Flags
fragrance-component
eu_children_restricted
epa_safer_alternative
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Laureth-50 by CAS number or substance name.
Studies
55
Lowest NOAEL
1
Highest NOAEL
4000
Units vary across source rows: mg/kg bw/day, mg/kg, mg/kg bw
ToxValDB_ECHA_IUCLID
FDA_Toxicity_652075c3-23dd-4b58-b6b0-8a16302f8993_dossier.i6z
CIR_vision_codex
Known Synonyms
alpha-Dodecyl-omega-hydroxypoly(oxyethylene)
Polyoxyethylene lauryl ether
Dodecyl poly(oxyethylene) ether
Poly(oxy-1,2-ethanediyl), alpha-dodecyl-omega-hydroxy-
EC No.: 500-002-6
Dodecyl alcohol, ethoxylated
Poly(oxy-1,2-ethanediyl), .alpha.-dodecyl-.omega.-hydroxy-
Ethoxylated dodecyl alcohol
Atlas G-2133
Atlas G-3705
Dodecanol, ethoxylate
Noniolite AL 20
alpha-Dodecyl-omega-hydroxypoly(oxy-1,2-ethanediyl)
Adeka Carpol M 2
Atossisclerol
Nonaethyleneglycol monododecyl ether
Polyoxyethylene 9-lauryl ether
Polyoxyethylenedodecyl ether
UNII-6HQ855798J
Chemical Function
Surfactant (surface active agent)
Regulatory Lists
active_ingredient; Pesticides
SCIL (9/2019)
Europe; Specialty occupational products
Indirect additives food contact (10/2018)
pharmaceutical
pharmaceutical
Canada; pharmaceutical
IFRA Transparency
Canada; consumer_product; Substances in Products - Canada (4/2014)
inert_ingredient; non_food_use; Pesticides
inert_ingredient; Pesticides
Europe; Personal care - body hygiene - hand soap
children; Europe; Personal care
children; Europe; Personal care - specialized bath products - bubble bath
Europe; Personal care - body hygiene - hand soap
pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
polidocanol
ChEMBL ID
CHEMBL1231723
Adverse Event Associations
59
Frequently Asked Questions
Is Laureth-50 allowed in the EU?
Laureth-50 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Laureth-50 do in cosmetics?
Laureth-50 functions as: Surfactant – emulsifying agent, surfactant – cleansing, fragrance functional. It is classified as a cosmetic ingredient in our database. CAS number: 9002-92-0.
What is the NOAEL for Laureth-50?
The NOAEL (No Observed Adverse Effect Level) for Laureth-50 is =7 mg/kg based on a repeated dose toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: CIR_vision_codex.
Is Laureth-50 used outside cosmetics?
Laureth-50 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Laureth-50 have different safety status in cosmetics vs industrial chemicals?
Laureth-50 is classified GHS Danger (H302, H315, H318, H319, H400, H412) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Laureth-50 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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