Also known as: alpha-Dodecyl-omega-hydroxypoly(oxyethylene), Polyoxyethylene lauryl ether, Dodecyl poly(oxyethylene) ether, Poly(oxy-1,2-ethanediyl), alpha-dodecyl-omega-hydroxy-, EC No.: 500-002-6 (+14 more)
INCI: LAURETH-50
Laureth-50 (CAS 9002-92-0) is a cosmetic cosmetic ingredient functioning as Surfactant – emulsifying agent, surfactant – cleansing, fragrance functional. NOAEL 100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; 5 safety opinions reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
US NotesPermitted – no specific CFR restriction; CIR-reviewed safe when formulated to be non-irritating
For full compliance data across multiple jurisdictions, use the
Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Laureth-50.
Calculate MoS for your specific formulation with the
MoS Calculator.
Toxicological Studies
10 study endpoints found for Laureth-50. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=7 mg/kg
oral
rat
repeated dose toxicity
CIR Safety Assessment
NOAEL
=7 mg/kg
oral
rat
repeated dose toxicity
CIR Safety Assessment
NOAEL
=7 mg/kg
oral
rat
repeated dose toxicity
CIR Safety Assessment
NOAEL
=7 mg/kg
oral
rat
repeated dose toxicity
CIR Safety Assessment
NOAEL
=190 mg/kg
oral
rat
oral toxicity
CIR Safety Assessment
NOAEL
=190 mg/kg
oral
rat
oral toxicity
CIR Safety Assessment
NOAEL
=190 mg/kg
oral
rat
oral toxicity
CIR Safety Assessment
NOAEL
=190 mg/kg
oral
rat
oral toxicity
CIR Safety Assessment
NOAEL
=300 mg/kg
-
-
NOAEL study
CIR Safety Assessment
NOAEL
=300 mg/kg
-
-
NOAEL study
CIR Safety Assessment
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
CIR Safety Assessment
Verdict: safe
NOAEL: 1.6 g/kg (oral)
polated from the existing data to support safety. The Panel concluded that the Alkyl PEG ethers are safe as used when formulated to be nonirritating, and the same applies to future alkyl PEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol
CIR Safety Assessment
Verdict: safe
NOAEL: 400 mg/kg (not specified)
polated from the existing data to support safety. The Panel concluded that the Alkyl PEG ethers are safe as used when formulated to be nonirritating, and the same applies to future alkyl PEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol
CIR Safety Assessment
Verdict: safe
NOAEL: 1200 mg/kg (not specified)
polated from the existing data to support safety. The Panel concluded that the Alkyl PEG ethers are safe as used when formulated to be nonirritating, and the same applies to future alkyl PEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol
CIR Safety Assessment
Verdict: safe
NOAEL: 4000 mg/kg (dermal)
polated from the existing data to support safety. The Panel concluded that the Alkyl PEG ethers are safe as used when formulated to be nonirritating, and the same applies to future alkyl PEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol
CIR Safety Assessment
Verdict: safe
NOAEL: 1650 mg/kg bw (not specified)
polated from the existing data to support safety. The Panel concluded that the Alkyl PEG ethers are safe as used when formulated to be nonirritating, and the same applies to future alkyl PEG ether cosmetic ingredients that vary from those ingredients recited herein only by the number of ethylene glycol
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Laureth-50 across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agentCleaning agentDegradant/impurityDeodorizerDispersing agentEmulsifierFragranceHeat stabilizerHumectantNo specific technical function
Regulatory List Membership (4)
EU Restricted for Children (Cosmetics)IFRA Fragrance Transparency ListEPA Safer Chemical Ingredients List (SCIL)FDA Indirect Food Contact Additives
Editorial summary
Preliminary editorial summary for Laureth-50 — not a computed safety verdict. See the sourced toxicological data above.
active_ingredient; PesticidesSCIL (9/2019)Europe; Specialty occupational productsIndirect additives food contact (10/2018)pharmaceuticalpharmaceuticalCanada; pharmaceuticalIFRA TransparencyCanada; consumer_product; Substances in Products - Canada (4/2014)inert_ingredient; non_food_use; Pesticidesinert_ingredient; PesticidesEurope; Personal care - body hygiene - hand soapchildren; Europe; Personal carechildren; Europe; Personal care - specialized bath products - bubble bathEurope; Personal care - body hygiene - hand soappharmaceutical
Australian Status
AICIS status:listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCEChEMBL / DrugCentral / FAERSDB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Laureth-50 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
Is Laureth-50 allowed in the EU?
Laureth-50 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Laureth-50 do in cosmetics?
Laureth-50 functions as: Surfactant – emulsifying agent, surfactant – cleansing, fragrance functional. It is classified as a cosmetic ingredient in our database. CAS number: 9002-92-0.
What is the NOAEL for Laureth-50?
The NOAEL (No Observed Adverse Effect Level) for Laureth-50 is =7 mg/kg based on a repeated dose toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: CIR Safety Assessment.
Is Laureth-50 used outside cosmetics?
Laureth-50 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Laureth-50 have different safety status in cosmetics vs industrial chemicals?
Laureth-50 is classified GHS Danger (H302, H315, H318, H319, H400, H412) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
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