What is the NOAEL for Poloxalene?
Poloxalene has 50 NOAEL studies in the database. The lowest reported value is 199SZS8E2Q UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Poloxalene
Also known as: 2-Methyl-oxirane polymer with oxirane, 1,2-Ethanediol, polymer with 1,2-propanediol, Ethylene glycol polyethylene-polypropylene glycol ether (1:2), Proxanol Tsl-3, Polyoxyethylene-oxy-propylene (+13 more)
CAS 9003-11-6
Poloxalene (CAS 9003-11-6) is a chemical substance. Key regulatory status: 18 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
50
SOURCE
chemical inventory jurisdictions
Regulatory lists
18
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
Poloxalene
CAS Number
9003-11-6
DTXSID
DTXSID4047597
Synonyms
2-Methyl-oxirane polymer with oxirane1,2-Ethanediol, polymer with 1,2-propanediolEthylene glycol polyethylene-polypropylene glycol ether (1:2)Proxanol Tsl-3Polyoxyethylene-oxy-propyleneEthylene oxide, propylene oxide block polymerUNII-52901V8XARUNII-P5QZM4T259UNII-66UUC8WX0DUNII-YWJ6837FL1UNII-68T8I45V23UNII-B9Y8J911BV
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Surfactant (surface active agent)Solvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
18 records
| List | Keyword | Source |
|---|---|---|
| fracking; water | NY Department of Conservation | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 50 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 199SZS8E2Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 199SZS8E2Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 199SZS8E2Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 199SZS8E2Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1AZW43116L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1AZW43116L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1AZW43116L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1AZW43116L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 52901V8XAR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 52901V8XAR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 52901V8XAR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 52901V8XAR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 66UUC8WX0D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 66UUC8WX0D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 66UUC8WX0D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 66UUC8WX0D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 68T8I45V23 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 68T8I45V23 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 68T8I45V23 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 68T8I45V23 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ETS9O8IMRZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ETS9O8IMRZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ETS9O8IMRZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ETS9O8IMRZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| JP0CK963E0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| JP0CK963E0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| JP0CK963E0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| JP0CK963E0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P5QZM4T259 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P5QZM4T259 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P5QZM4T259 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P5QZM4T259 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.32 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =500 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =0.5 | % weight | LOEL | oral | Rat | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 40 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 100 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 200 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 400 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 480 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3750 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 5000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 25000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 30000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 50 of 50 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Poloxalene?
Poloxalene appears on 9 regulatory/inventory lists including fracking; water, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), inert_ingredient; non_food_use; Pesticides, and 6 more. Source: EPA CPDat.
Is Poloxalene used in cosmetics?
Yes, Poloxalene is also indexed as a cosmetic ingredient under the name Cubosomes. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Poloxalene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Poloxalene used outside industrial chemicals?
Poloxalene also appears in cosmetics, food safety, cannabis databases.