Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Cubosomes. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 25000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 30000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 480 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 3000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 40 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
Expert Verdict
Cubosomes lack sufficient safety data; further assessment is recommended before widespread use.
Regulatory Flags
Frequently Asked Questions
Is Cubosomes safe in cosmetics?
Cubosomes lack sufficient safety data; further assessment is recommended before widespread use. The EU classifies Cubosomes as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Cubosomes allowed in the EU?
Cubosomes EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cubosomes do in cosmetics?
Cubosomes functions as: Advanced nanocarrier delivery systems for cosmetic actives. It is classified as a Active Ingredient in our database. CAS number: 9003-11-6.
What is the Margin of Safety for Cubosomes?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Cubosomes?
The NOAEL (No Observed Adverse Effect Level) for Cubosomes is 25000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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