What is the NOAEL for Methylpolysilicone?
Methylpolysilicone has 2 NOAEL studies in the database. The lowest reported value is 150 mg/kg bw/day via oral in rat. Source: COSMOS_DB.
NOAEL Data
Cosmetic Ingredient
Methylpolysilicone
CAS 9004-73-3
Methylpolysilicone (CAS 9004-73-3) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
2
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
3 fields
Name
Methylpolysilicone
CAS Number
9004-73-3
DTXSID
DTXSID8047501
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Wetting agent (non-aqueous)Lubricating agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 2 of 2 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 150 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 300 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
Showing 2 of 2 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
emollient
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Methylpolysilicone?
Methylpolysilicone appears on 1 regulatory/inventory list including food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Methylpolysilicone used in cosmetics?
Yes, Methylpolysilicone is also indexed as a cosmetic ingredient under the name Methicone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Methylpolysilicone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Methylpolysilicone used outside industrial chemicals?
Methylpolysilicone also appears in cosmetics, food safety databases.