Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Methicone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 300 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 150 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
Expert Verdict
Linear silicone with one methyl and one hydrogen substituent per silicon. Included in CIR Final Amended Report March 2022 covering 30 methicone/dimethicone polymers, all concluded safe as used. Not subject to EU cyclic siloxane restrictions. Provides good emollient and conditioning properties with negligible skin penetration and no sensitization concerns.
Regulatory Flags
Frequently Asked Questions
Is Methicone safe in cosmetics?
Linear silicone with one methyl and one hydrogen substituent per silicon. Included in CIR Final Amended Report March 2022 covering 30 methicone/dimethicone polymers, all concluded safe as used. Not subject to EU cyclic siloxane restrictions. Provides good emollient and conditioning properties with negligible skin penetration and no sensitization concerns. The EU classifies Methicone as "permitted". Safety rating: EXCELLENT. 2 toxicological study endpoint(s) are available in our database.
Is Methicone allowed in the EU?
Methicone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methicone do in cosmetics?
Methicone functions as: emollient, skin-conditioning, film-forming. It is classified as a Emollient in our database. CAS number: 9004-73-3.
What is the Margin of Safety for Methicone?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methicone?
The NOAEL (No Observed Adverse Effect Level) for Methicone is 300 mg/kg bw/day based on a Chronic study via oral route in dog. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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