NOAEL Data Cosmetic Ingredient

Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-hydroxy-

Also known as: Cremophor A, Crill 20,21,22,23, Emcol H 35-A, Empilan CP-100, Empilan CQ-100 (+14 more)

CAS 9004-99-3

Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-hydroxy- (CAS 9004-99-3) is a chemical substance. Key regulatory status: 16 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for PEG-100 Stearate →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
16
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 22 fields
Name
Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-hydroxy-
CAS Number
9004-99-3
DTXSID
DTXSID6027715
Synonyms
Cremophor ACrill 20,21,22,23Emcol H 35-AEmpilan CP-100Empilan CQ-100Emulphor VT-650Emunon 3115Glycol polyethylene monostearate #200Glycol, polyethylene monostearate #6000Ionet MS-1000Kessco X-211Lipal 400-S

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
SolventSurfactant (surface active agent)Cleaning agentHumectantEmulsifier

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 16 records
ListKeywordSource
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - general moisturizing - hand/body lotionDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Canada; pharmaceuticalDrugBankDrugBank
CEDIFDAUnited States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - general moisturizing - hand/body lotionDanish Environmental Protection AgencyDanish EPA
IFRA TransparencyIFRAIFRA
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
SCIL (9/2019)USEPASafer Chemical Ingredients List
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
inert_ingredient; PesticidesEPACPCat
inert_ingredient; non_food_use; PesticidesEPACPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
-unitlessDraize rabbit irritation scoreOcularRabbitNTP_ICE_eye_irritation
0V73PIX5YCUNIIFDA UNII substance identifier--openFDA substances
0V73PIX5YCUNIIFDA UNII substance identifier--openFDA substances
0V73PIX5YCUNIIFDA UNII substance identifier--openFDA substances
0V73PIX5YCUNIIFDA UNII substance identifier--openFDA substances
1J2956FWUBUNIIFDA UNII substance identifier--openFDA substances
1J2956FWUBUNIIFDA UNII substance identifier--openFDA substances
1J2956FWUBUNIIFDA UNII substance identifier--openFDA substances
1J2956FWUBUNIIFDA UNII substance identifier--openFDA substances
1U8KB35S20UNIIFDA UNII substance identifier--openFDA substances
1U8KB35S20UNIIFDA UNII substance identifier--openFDA substances
1U8KB35S20UNIIFDA UNII substance identifier--openFDA substances
1U8KB35S20UNIIFDA UNII substance identifier--openFDA substances
1X2OAT3BFKUNIIFDA UNII substance identifier--openFDA substances
1X2OAT3BFKUNIIFDA UNII substance identifier--openFDA substances
2P9L47VI5EUNIIFDA UNII substance identifier--openFDA substances
2P9L47VI5EUNIIFDA UNII substance identifier--openFDA substances
2P9L47VI5EUNIIFDA UNII substance identifier--openFDA substances
2P9L47VI5EUNIIFDA UNII substance identifier--openFDA substances
33GX5WQC0MUNIIFDA UNII substance identifier--openFDA substances
33GX5WQC0MUNIIFDA UNII substance identifier--openFDA substances
33GX5WQC0MUNIIFDA UNII substance identifier--openFDA substances
33GX5WQC0MUNIIFDA UNII substance identifier--openFDA substances
3954DT14A6UNIIFDA UNII substance identifier--openFDA substances
3954DT14A6UNIIFDA UNII substance identifier--openFDA substances
3954DT14A6UNIIFDA UNII substance identifier--openFDA substances
3954DT14A6UNIIFDA UNII substance identifier--openFDA substances
4L5ODS320SUNIIFDA UNII substance identifier--openFDA substances
4L5ODS320SUNIIFDA UNII substance identifier--openFDA substances
4L5ODS320SUNIIFDA UNII substance identifier--openFDA substances
4L5ODS320SUNIIFDA UNII substance identifier--openFDA substances
569T0R267JUNIIFDA UNII substance identifier--openFDA substances
569T0R267JUNIIFDA UNII substance identifier--openFDA substances
569T0R267JUNIIFDA UNII substance identifier--openFDA substances
569T0R267JUNIIFDA UNII substance identifier--openFDA substances
5I60X40576UNIIFDA UNII substance identifier--openFDA substances
5I60X40576UNIIFDA UNII substance identifier--openFDA substances
5I60X40576UNIIFDA UNII substance identifier--openFDA substances
5I60X40576UNIIFDA UNII substance identifier--openFDA substances
5WD387V180UNIIFDA UNII substance identifier--openFDA substances
5WD387V180UNIIFDA UNII substance identifier--openFDA substances
5WD387V180UNIIFDA UNII substance identifier--openFDA substances
5WD387V180UNIIFDA UNII substance identifier--openFDA substances
776CJK5X56UNIIFDA UNII substance identifier--openFDA substances
776CJK5X56UNIIFDA UNII substance identifier--openFDA substances
776CJK5X56UNIIFDA UNII substance identifier--openFDA substances
776CJK5X56UNIIFDA UNII substance identifier--openFDA substances
7BSG7DF10QUNIIFDA UNII substance identifier--openFDA substances
7BSG7DF10QUNIIFDA UNII substance identifier--openFDA substances
7BSG7DF10QUNIIFDA UNII substance identifier--openFDA substances

Showing 50 of 100 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
25%
Category
emulsifier
View full cosmetic safety profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E431 — ADI: 0-25 mg/kg bw mg/kg bw

View full food safety profile →

Frequently Asked Questions

What is the NOAEL for Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-hydroxy-?

Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-hydroxy- has 100 NOAEL studies in the database. The lowest reported value is 0 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.

What regulatory lists include Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-hydroxy-?

Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-hydroxy- appears on 12 regulatory/inventory lists including children; Europe; Personal care, children; Europe; Personal care - general moisturizing - hand/body lotion, Europe; Personal care, and 9 more. Source: EPA CPDat.

Is Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-hydroxy- used in cosmetics?

Yes, Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-hydroxy- is also indexed as a cosmetic ingredient under the name PEG-100 Stearate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-hydroxy- come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Is Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-hydroxy- used outside industrial chemicals?

Poly(oxy-1,2-ethanediyl), .alpha.-(1-oxooctadecyl)-.omega.-hydroxy- also appears in cosmetics, food safety databases.