Warning GHS07GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

4-Hydroxypropylamino-3-nitrophenol

Also known as: UNII-X89W3M6X79, 4-((3-Hydroxypropyl)amino)-3-nitrophenol, Phenol, 4-((3-hydroxypropyl)amino)-3-nitro-, Colorex RBN, Covariane Rouge W 3127 (+4 more)

CAS 92952-81-3

4-Hydroxypropylamino-3-nitrophenol (CAS 92952-81-3) is a chemical substance with GHS signal word Warning; key hazard signal: H315; H411. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 4-Hydroxypropylamino-3-Nitrophenol →

SOURCE NOAEL studies
NOAEL studies
17
SOURCE Chemical inventory jurisdictions
Regulatory lists
6
SOURCE EU CLP Annex VI
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 14 fields
Name
4-Hydroxypropylamino-3-nitrophenol
CAS Number
92952-81-3
Molecular Formula
C9H12N2O4
InChI Key
VTXBLQLZQLHDIL-UHFFFAOYSA-N
Monoisotopic Mass
212.079707
Synonyms
UNII-X89W3M6X794-((3-Hydroxypropyl)amino)-3-nitrophenolPhenol, 4-((3-hydroxypropyl)amino)-3-nitro-Colorex RBNCovariane Rouge W 3127HC Red BNPlakatrot Z3-(4-Idrossi-2-nitroanilino)propanolo3-(4-Hydroxy-2-nitroanilino)propanol

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Skin Irrit. 2; Aquatic Chronic 2H315; H411GHS07; GHS09Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng
Canada; Personal care; Substances in PCP - Canada (4/2014)Government of CanadaCPCat
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 17 of 17 studies
ValueUnitEndpointRouteSpeciesSource
10mg/kg bw---Regulatory source
90mg/kg bw/day---Regulatory source
X89W3M6X79UNIIFDA UNII substance identifier--openFDA substances
10mg/kg bw/dayLOAELoralratCOSMOS DB
=0.02mg/kgNOAELoralratSCCS Opinion
=0.067mg/kgNOAELoralratSCCS Opinion
=10mg/kg bwNOAELoralratSCCS Opinion
=30mg/kg bw/dayNOAEL--SCCS Opinion
=30mg/kgNOAELoralratSCCS Opinion
=90mg/kg bw/dayNOAEL--SCCS Opinion
=0.02mg/kgdermal absorptionoralratRegulatory source
=0.067mg/kgdermal absorptionoralratRegulatory source
=30mg/kgdermal absorptionoralratRegulatory source
90mg/kg bw/daydevelopmental toxicity-ratRegulatory source
30mg/kg bw/daygenotoxicity--Regulatory source
30mg/kg bw/dayirritation-ratRegulatory source
10mg/kg bwrepeated dose toxicityoralratRegulatory source

Showing 17 of 17 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registered4-[(3-hydroxypropyl)amino]-3-nitrophenol406-305-9ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/1113/0718 December 2007safe2.6%secondary amine; nitrosamine <50ppb; sensitisation not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the GHS hazard classification for 4-Hydroxypropylamino-3-nitrophenol?

4-Hydroxypropylamino-3-nitrophenol (CAS 92952-81-3) is classified under EU CLP Annex VI as Skin Irrit. 2; Aquatic Chronic 2 with signal word Warning. Hazard statements: H315; H411. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 4-Hydroxypropylamino-3-nitrophenol?

4-Hydroxypropylamino-3-nitrophenol has 17 NOAEL studies in the database. The lowest reported value is 10 mg/kg bw. Source: Regulatory source.

What regulatory lists include 4-Hydroxypropylamino-3-nitrophenol?

4-Hydroxypropylamino-3-nitrophenol appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; Personal care - hair coloring. Source: EPA CPDat.

Is 4-Hydroxypropylamino-3-nitrophenol used in cosmetics?

Yes, 4-Hydroxypropylamino-3-nitrophenol is also indexed as a cosmetic ingredient under the name 4-Hydroxypropylamino-3-Nitrophenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-Hydroxypropylamino-3-nitrophenol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 4-Hydroxypropylamino-3-nitrophenol have different safety status in cosmetics vs industrial chemicals?

4-Hydroxypropylamino-3-nitrophenol is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H411).

Is 4-Hydroxypropylamino-3-nitrophenol used outside industrial chemicals?

4-Hydroxypropylamino-3-nitrophenol also appears in cosmetics databases.