Is 4-Hydroxypropylamino-3-Nitrophenol safe in cosmetics?
4-Hydroxypropylamino-3-Nitrophenol has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
4-Hydroxypropylamino-3-Nitrophenol
Also known as: UNII-X89W3M6X79, 4-((3-Hydroxypropyl)amino)-3-nitrophenol, Phenol, 4-((3-hydroxypropyl)amino)-3-nitro-, Colorex RBN, Covariane Rouge W 3127 (+4 more)
INCI: 4-HYDROXYPROPYLAMINO-3-NITROPHENOL
4-Hydroxypropylamino-3-Nitrophenol (CAS 92952-81-3) is a cosmetic cosmetic ingredient functioning as Hair dyeing (oxidative and semi-permanent). Reported NOAEL =0.02 mg/kg in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 92952-81-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
4-Hydroxypropylamino-3-Nitrophenol is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H411).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing (oxidative and semi-permanent)
Safety Rating
GOOD
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted for use in hair dye formulations under the coal-tar exemption
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 4-Hydroxypropylamino-3-Nitrophenol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 4-Hydroxypropylamino-3-Nitrophenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.02 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.02 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.02 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.02 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.067 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.067 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.067 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.067 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =10 mg/kg bw | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =10 mg/kg bw | oral | rat | repeated dose toxicity | SCCS_vision_codex |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / IrritantEnvironmental Hazard
Hazard Class and Category
Skin Irrit. 2; Aquatic Chronic 2
Hazard Statements
- H315 Causes skin irritation
- H411 Toxic to aquatic life with long lasting effects
Inserted via ATP: CLP00
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Lys %
57.22%
KeratinoSens IC50
1204.498 µM
hCLAT CV75
750 µg/mL
LLNA EC3
50%
NESIL
12500 µg/cm²
LLNA: Weak (1B)
GHS: 1B
Source: LLNA: CosmEur database; DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products. Max: (b) 2.6%.
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 2.6%
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "92952-81-3", "ingredient_class": "direct_dye", "chemical_class": "nitro", "color_result_on_hair": "Red-yellow", "shade_range": "red", "primary_function": "direct_deposit", "requires_developer": "no", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-10", "light_fastness": "moderate", "oxidation_mechanism": "direct_absorption", "hair_penetration_dep…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 4-Hydroxypropylamino-3-Nitrophenol.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 4-Hydroxypropylamino-3-Nitrophenol by CAS number or substance name.
Studies
24
Lowest NOAEL
0.02
Highest NOAEL
90
Units vary across source rows: mg/kg bw, mg/kg bw/day, mg/kg
SCCS_vision_codex
Known Synonyms
UNII-X89W3M6X79
4-((3-Hydroxypropyl)amino)-3-nitrophenol
Phenol, 4-((3-hydroxypropyl)amino)-3-nitro-
Colorex RBN
Covariane Rouge W 3127
HC Red BN
Plakatrot Z
3-(4-Idrossi-2-nitroanilino)propanolo
3-(4-Hydroxy-2-nitroanilino)propanol
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Canada; Personal care; Substances in PCP - Canada (4/2014)
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 4-Hydroxypropylamino-3-Nitrophenol allowed in the EU?
4-Hydroxypropylamino-3-Nitrophenol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-Hydroxypropylamino-3-Nitrophenol do in cosmetics?
4-Hydroxypropylamino-3-Nitrophenol functions as: Hair dyeing (oxidative and semi-permanent). It is classified as a cosmetic ingredient in our database. CAS number: 92952-81-3.
What is the NOAEL for 4-Hydroxypropylamino-3-Nitrophenol?
The NOAEL (No Observed Adverse Effect Level) for 4-Hydroxypropylamino-3-Nitrophenol is =0.02 mg/kg based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is 4-Hydroxypropylamino-3-Nitrophenol used outside cosmetics?
4-Hydroxypropylamino-3-Nitrophenol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 4-Hydroxypropylamino-3-Nitrophenol have different safety status in cosmetics vs industrial chemicals?
4-Hydroxypropylamino-3-Nitrophenol is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H411).
Compliance Tools
Check 4-Hydroxypropylamino-3-Nitrophenol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acid Blue 9
Excellent
Same category
Colorant, Hair Dyeing
Acid Blue 9 Aluminum Lake
Excellent
Same category
Colorant
Anthocyanins
Excellent
Same category
Colorant
Beta Vulgaris Extract
Excellent
Same category
Skin Conditioning, Colorant (betalain...
Beta Vulgaris Root Extract
Excellent
Same category
Skin Conditioning, Colorant (betanin/...
Beta Vulgaris Root Powder
Excellent
Same category
Skin conditioning, natural colorant, ...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
4-Hydroxy-2-Methoxybenzaldehyde
Good
Browse nearby
Fragrance
4-Hydroxybenzoic Acid
Excellent
Browse nearby
Preservative, pH Balancer
4-Hydroxybutyl Acrylate
Moderate
Browse nearby
Binding agent that ensures cohesion o...
Is 4-Hydroxypropylamino-3-Nitrophenol in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 4-Hydroxypropylamino-3-Nitrophenol in your formulation.