What is the NOAEL for Acetyleugenol?
Acetyleugenol has 11 NOAEL studies in the database. The lowest reported value is V9OSB376X8 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Acetyleugenol
Also known as: 4-Allyl-2-methoxyphenyl acetate, Eugenol acetate, 2-Methoxy-4-(prop-2-en-1-yl)phenyl acetate, 2-Methoxy-4-(2-propenyl)phenyl acetate, Phenol, 4-allyl-2-methoxy-, acetate (+13 more)
CAS 93-28-7
Acetyleugenol (CAS 93-28-7) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Acetyleugenol is prohibited in EU cosmetics but has active industrial GHS classifications (H302).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
Acetyleugenol
CAS Number
93-28-7
DTXSID
DTXSID5052624
Molecular Formula
C12H14O3
InChI Key
SCCDQYPEOIRVGX-UHFFFAOYSA-N
Monoisotopic Mass
206.094294
Synonyms
4-Allyl-2-methoxyphenyl acetateEugenol acetate2-Methoxy-4-(prop-2-en-1-yl)phenyl acetate2-Methoxy-4-(2-propenyl)phenyl acetatePhenol, 4-allyl-2-methoxy-, acetate3-06-00-05029Aceteugenol1-Acetoxy-2-methoxy-4-allylbenzeneAcetyl eugenol4-Allyl-2-methoxyphenol acetateBRN 1964745EINECS 202-235-6
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
DeodorizerFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| V9OSB376X8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| V9OSB376X8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| V9OSB376X8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| V9OSB376X8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 12960 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =1670 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =300 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-allyl-2-methoxyphenyl acetate | 202-235-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
EUGENYL ACETATE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Acetyleugenol?
Acetyleugenol appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Acetyleugenol used in cosmetics?
Yes, Acetyleugenol is also indexed as a cosmetic ingredient under the name Eugenyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Acetyleugenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Acetyleugenol have different safety status in cosmetics vs industrial chemicals?
Acetyleugenol is prohibited in EU cosmetics but has active industrial GHS classifications (H302).
Is Acetyleugenol used outside industrial chemicals?
Acetyleugenol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.