Good Cosmetic Ingredient NOAEL Data

Eugenyl Acetate

INCI: EUGENYL ACETATE

CAS Number
93-28-7
Function
Fragrance / Masking
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no specific 21 CFR cosmetic restriction; FEMA GRAS for food flavoring

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Eugenyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 1000 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Rapidly hydrolyzes to eugenol in hepatic microsomes. Eugenol is a known fragrance allergen with mandatory EU label declaration. Not genotoxic and not PBT; readily biodegradable.

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Eugenyl Acetate safe in cosmetics?

Rapidly hydrolyzes to eugenol in hepatic microsomes. Eugenol is a known fragrance allergen with mandatory EU label declaration. Not genotoxic and not PBT; readily biodegradable. The EU classifies Eugenyl Acetate as "prohibited". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Eugenyl Acetate allowed in the EU?

Eugenyl Acetate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Eugenyl Acetate do in cosmetics?

Eugenyl Acetate functions as: Fragrance / Masking. It is classified as a cosmetic ingredient in our database. CAS number: 93-28-7.

What is the Margin of Safety for Eugenyl Acetate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Eugenyl Acetate?

The NOAEL (No Observed Adverse Effect Level) for Eugenyl Acetate is 1000 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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