NOAEL Data REACH Registered Cosmetic Ingredient

Hydroxyethyl-p-phenylenediamine sulphate

CAS 93841-25-9

Hydroxyethyl-p-phenylenediamine sulphate (CAS 93841-25-9) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Hydroxyethyl-p-Phenylenediamine Sulfate →

SOURCE NOAEL studies
NOAEL studies
92
SOURCE Chemical inventory jurisdictions
Regulatory lists
3
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 6 fields
Name
Hydroxyethyl-p-phenylenediamine sulphate
CAS Number
93841-25-9
DTXSID
DTXSID90879808
Molecular Formula
C8H12N2O.H2O4S
InChI Key
VBSLNFWECRRALP-UHFFFAOYSA-N
Monoisotopic Mass
250.062343

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng
Canada; Personal care; Substances in PCP - Canada (4/2014)Government of CanadaCPCat
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 92 studies
ValueUnitEndpointRouteSpeciesSource
25mg/kg bw-oralratRegulatory source
2000mg/kg bw-dermalratRegulatory source
2000mg/kg bw-dermal-Regulatory source
=2.12mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
L8W90PN89RUNIIFDA UNII substance identifier--openFDA substances
L8W90PN89RUNIIFDA UNII substance identifier--openFDA substances
L8W90PN89RUNIIFDA UNII substance identifier--openFDA substances
L8W90PN89RUNIIFDA UNII substance identifier--openFDA substances
=0.035mg/kg bwNOAELoralratSCCS Opinion
=0.035mg/kg bwNOAELoralratSCCS Opinion
=0.035mg/kg bwNOAELoralratSCCS Opinion
=0.035mg/kg bwNOAELoralratSCCS Opinion
=25mg/kg bwNOAELoralratSCCS Opinion
=25mg/kg bw/dayNOAEL-ratSCCS Opinion
=25mg/kg bwNOAELoralratSCCS Opinion
=25mg/kg bw/dayNOAEL-ratSCCS Opinion
=25mg/kg bwNOAELoralratSCCS Opinion
=25mg/kg bw/dayNOAEL-ratSCCS Opinion
=25mg/kg bwNOAELoralratSCCS Opinion
=25mg/kg bw/dayNOAEL-ratSCCS Opinion
=30mg/kg bw/dayNOAELoralRatECHA
=30mg/kg/dayNOAEL--SCCS Opinion
=30mg/kgNOAELoralratSCCS Opinion
=30mg/kg/dayNOAEL-humanSCCS Opinion
=30mg/kg bw/dNOAELoralratSCCS Opinion
=30mg/kg/dayNOAEL--SCCS Opinion
=30mg/kgNOAELoralratSCCS Opinion
=30mg/kg/dayNOAEL--SCCS Opinion
=30mg/kgNOAELoralratSCCS Opinion
=30mg/kg/dayNOAEL-humanSCCS Opinion
=30mg/kg bw/dNOAELoralratSCCS Opinion
=30mg/kg/dayNOAEL-humanSCCS Opinion
=30mg/kg bw/dNOAELoralratSCCS Opinion
=30mg/kg/dayNOAEL--SCCS Opinion
=30mg/kgNOAELoralratSCCS Opinion
=30mg/kg/dayNOAEL-humanSCCS Opinion
=30mg/kg bw/dNOAELoralratSCCS Opinion
=35mg/kg bw/dayNOAELoralRatECHA
=35mg/kg bwNOAELoralratSCCS Opinion
=35mg/kg bwNOAELoralratSCCS Opinion
=35mg/kg bwNOAELoralratSCCS Opinion
=35mg/kg bwNOAELoralratSCCS Opinion
=35mg/kg bwNOAELoralratSCCS Opinion
=35mg/kg bwNOAELoralratSCCS Opinion
=35mg/kg bwNOAELoralratSCCS Opinion
=35mg/kg bwNOAELoralratSCCS Opinion
=55mg/kg bw/dayNOAEL-ratSCCS Opinion
=55mg/kg bw/dayNOAEL-ratSCCS Opinion
=55mg/kg bw/dayNOAEL-ratSCCS Opinion
=55mg/kg bw/dayNOAEL-ratSCCS Opinion

Showing 50 of 92 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registered3-(2-hydroxyethyl)-p-phenylenediammonium sulphate298-995-1ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
2.0%
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for Hydroxyethyl-p-phenylenediamine sulphate?

Hydroxyethyl-p-phenylenediamine sulphate has 92 NOAEL studies in the database. The lowest reported value is 0.035 mg/kg bw via oral in rat. Source: Regulatory source.

What regulatory lists include Hydroxyethyl-p-phenylenediamine sulphate?

Hydroxyethyl-p-phenylenediamine sulphate appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; Personal care - hair coloring. Source: EPA CPDat.

Is Hydroxyethyl-p-phenylenediamine sulphate used in cosmetics?

Yes, Hydroxyethyl-p-phenylenediamine sulphate is also indexed as a cosmetic ingredient under the name Hydroxyethyl-p-Phenylenediamine Sulfate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Hydroxyethyl-p-phenylenediamine sulphate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does Hydroxyethyl-p-phenylenediamine sulphate have different safety status in cosmetics vs industrial chemicals?

Hydroxyethyl-p-phenylenediamine sulphate is prohibited in EU cosmetics at max 2.0% but has active industrial GHS classifications (H301, H317, H373, H411, H319).

Is Hydroxyethyl-p-phenylenediamine sulphate used outside industrial chemicals?

Hydroxyethyl-p-phenylenediamine sulphate also appears in cosmetics databases.