NOAEL Data REACH Registered Cosmetic Ingredient

Hydroxyethyl-3,4-methylenedioxyaniline HCl

Also known as: EINECS 303-085-5, UNII-8IRK9YBY3K

CAS 94158-14-2

Hydroxyethyl-3,4-methylenedioxyaniline HCl (CAS 94158-14-2) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Hydroxyethyl-3,4-Methylenedioxyaniline HCl →

SOURCE NOAEL studies
NOAEL studies
44
SOURCE Chemical inventory jurisdictions
Regulatory lists
3
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 8 fields
Name
Hydroxyethyl-3,4-methylenedioxyaniline HCl
CAS Number
94158-14-2
DTXSID
DTXSID20240825
Molecular Formula
C9H11NO3.ClH
InChI Key
LMONVTDNVNEAQG-UHFFFAOYSA-N
Monoisotopic Mass
217.050571
Synonyms
EINECS 303-085-5UNII-8IRK9YBY3K

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng
Canada; Personal care; Substances in PCP - Canada (4/2014)Government of CanadaCPCat
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 44 of 44 studies
ValueUnitEndpointRouteSpeciesSource
20mg/kg-oralrabbitRegulatory source
=25.7mg/kg bw--humanRegulatory source
50mg/kg bw---Regulatory source
50mg/kg bw---Regulatory source
50mg/kg bw--humanRegulatory source
50mg/kg bw--humanRegulatory source
8IRK9YBY3KUNIIFDA UNII substance identifier--openFDA substances
8IRK9YBY3KUNIIFDA UNII substance identifier--openFDA substances
8IRK9YBY3KUNIIFDA UNII substance identifier--openFDA substances
8IRK9YBY3KUNIIFDA UNII substance identifier--openFDA substances
100mg/kg bw/dayLOAELoralratCOSMOS DB
20mg/kg bw/dayNOAELoralratCOSMOS DB
=20mg/kg bw/dayNOAELoralRatECHA
=20mg/kg/dNOAELoralratCIR Safety Assessment
=20mg/kg bw/dayNOAEL-ratSCCS Opinion
=20mg/kgNOAELoralrabbitSCCS Opinion
=20mg/kg/dNOAELoralratCIR Safety Assessment
=20mg/kg bw/dayNOAEL-ratSCCS Opinion
=20mg/kgNOAELoralrabbitSCCS Opinion
=20mg/kg/dNOAELoralratCIR Safety Assessment
=20mg/kg bw/dayNOAEL-ratSCCS Opinion
=20mg/kgNOAELoralrabbitSCCS Opinion
=20mg/kg/dNOAELoralratCIR Safety Assessment
=20mg/kg bw/dayNOAEL-ratSCCS Opinion
=20mg/kgNOAELoralrabbitSCCS Opinion
=25.7mg/kg bwNOAEL-humanSCCS Opinion
=25.7mg/kg bwNOAEL-humanSCCS Opinion
=25.7mg/kg bwNOAEL-humanSCCS Opinion
=25.7mg/kg bwNOAEL-humanSCCS Opinion
=26mg/kg bw/dayNOAELoralRatECHA
=26mg/kg/dNOAEL-mouseCIR Safety Assessment
=26mg/kg/dNOAEL-mouseCIR Safety Assessment
=26mg/kg/dNOAEL-mouseCIR Safety Assessment
=26mg/kg/dNOAEL-mouseCIR Safety Assessment
=50mg/kg bwNOAEL--SCCS Opinion
=50mg/kg bwNOAEL--SCCS Opinion
=50mg/kg bwNOAEL--SCCS Opinion
=50mg/kg bwNOAEL--SCCS Opinion
20mg/kg/ddevelopmental toxicityoralratRegulatory source
20mg/kg bw/daydevelopmental toxicity-ratRegulatory source
20mg/kg bw/daydevelopmental toxicity-ratRegulatory source
20mg/kg bw/daydevelopmental toxicity-ratRegulatory source
26mg/kg/ddevelopmental toxicity-mouseRegulatory source
20mg/kg bw/daygenotoxicity-ratRegulatory source

Showing 44 of 44 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registered2-(1,3-benzodioxol-5-ylamino)ethanol hydrochloride303-085-5ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1388/108 December 2009safe1.5%sensitisation not excluded
SCCP/0909/0528 March 2006safe1.5%sensitisation not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
1.5%
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for Hydroxyethyl-3,4-methylenedioxyaniline HCl?

Hydroxyethyl-3,4-methylenedioxyaniline HCl has 44 NOAEL studies in the database. The lowest reported value is 20 mg/kg via oral in rabbit. Source: Regulatory source.

What regulatory lists include Hydroxyethyl-3,4-methylenedioxyaniline HCl?

Hydroxyethyl-3,4-methylenedioxyaniline HCl appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; Personal care - hair coloring. Source: EPA CPDat.

Is Hydroxyethyl-3,4-methylenedioxyaniline HCl used in cosmetics?

Yes, Hydroxyethyl-3,4-methylenedioxyaniline HCl is also indexed as a cosmetic ingredient under the name Hydroxyethyl-3,4-Methylenedioxyaniline HCl. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Hydroxyethyl-3,4-methylenedioxyaniline HCl come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is Hydroxyethyl-3,4-methylenedioxyaniline HCl used outside industrial chemicals?

Hydroxyethyl-3,4-methylenedioxyaniline HCl also appears in cosmetics databases.