Hydroxyethyl-3,4-Methylenedioxyaniline HCl
INCI: HYDROXYETHYL-3,4-METHYLENEDIOXYANILINE HCL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Hydroxyethyl-3,4-Methylenedioxyaniline HCl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 20 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 100 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 20 mg/kg bw/day | oral | rat | oral | REACH |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Expert Verdict
Restricted in EU with mandatory warnings per Annex III conditions; contains/may release methylene dioxyphenyl moiety; sensitization potential requires patch-test instruction on consumer products; must not exceed maximum on-head concentration.
Regulatory Flags
Frequently Asked Questions
Is Hydroxyethyl-3,4-Methylenedioxyaniline HCl safe in cosmetics?
Restricted in EU with mandatory warnings per Annex III conditions; contains/may release methylene dioxyphenyl moiety; sensitization potential requires patch-test instruction on consumer products; must not exceed maximum on-head concentration. The EU classifies Hydroxyethyl-3,4-Methylenedioxyaniline HCl as "restricted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is Hydroxyethyl-3,4-Methylenedioxyaniline HCl allowed in the EU?
Hydroxyethyl-3,4-Methylenedioxyaniline HCl EU regulatory status: restricted. Maximum allowed concentration: 1.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxyethyl-3,4-Methylenedioxyaniline HCl do in cosmetics?
Hydroxyethyl-3,4-Methylenedioxyaniline HCl functions as: Oxidative hair dye precursor (coupler). It is classified as a cosmetic ingredient in our database. CAS number: 94158-14-2.
What is the Margin of Safety for Hydroxyethyl-3,4-Methylenedioxyaniline HCl?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Hydroxyethyl-3,4-Methylenedioxyaniline HCl?
The NOAEL (No Observed Adverse Effect Level) for Hydroxyethyl-3,4-Methylenedioxyaniline HCl is 20 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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