NOAEL Data Cosmetic Ingredient

Methyl 2-[(3-phenyl-2-propen-1-ylidene)amino]benzoate

Also known as: Methyl 2-(cinnamylideneamino)benzoate, EINECS 305-271-1

CAS 94386-48-8

Methyl 2-[(3-phenyl-2-propen-1-ylidene)amino]benzoate (CAS 94386-48-8) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for Cinnamaldehyde/Methyl Anthranilate Schiff Base →

SOURCE NOAEL studies
NOAEL studies
20
SOURCE Chemical inventory jurisdictions
Regulatory lists
0
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 7 fields
Name
Methyl 2-[(3-phenyl-2-propen-1-ylidene)amino]benzoate
CAS Number
94386-48-8
Molecular Formula
C17H15NO2
InChI Key
OOJFPYZBLJTFST-UHFFFAOYSA-N
Monoisotopic Mass
265.110279
Synonyms
Methyl 2-(cinnamylideneamino)benzoateEINECS 305-271-1

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records
Fragrance

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 20 of 20 studies
ValueUnitEndpointRouteSpeciesSource
1.875%Concentration, 5% incidence of positive responsesDermalHumanNTP ICE skin sensitization
7.5%Concentration, 5% incidence of positive responsesDermalHumanNTP ICE skin sensitization
17.4%Concentration, 5% incidence of positive responsesDermalHumanNTP ICE skin sensitization
1.5%Concentration, one positive responseDermalHumanNTP ICE skin sensitization
2.4%Concentration, one positive responseDermalHumanNTP ICE skin sensitization
6%Concentration, one positive responseDermalHumanNTP ICE skin sensitization
12%Concentration, one positive responseDermalHumanNTP ICE skin sensitization
3.448%Incidence of positive responsesDermalHumanNTP ICE skin sensitization
8%Incidence of positive responsesDermalHumanNTP ICE skin sensitization
20%Incidence of positive responsesDermalHumanNTP ICE skin sensitization
32%Incidence of positive responsesDermalHumanNTP ICE skin sensitization
8100ug/cm2Induction dose per skin areaDermalHumanNTP ICE skin sensitization
1266ug/cm2Induction dose per skin area, 5% incidence of positive responsesDermalHumanNTP ICE skin sensitization
2025ug/cm2Induction dose per skin area, 5% incidence of positive responsesDermalHumanNTP ICE skin sensitization
5063ug/cm2Induction dose per skin area, 5% incidence of positive responsesDermalHumanNTP ICE skin sensitization
1.175e+4ug/cm2Induction dose per skin area, 5% incidence of positive responsesDermalHumanNTP ICE skin sensitization
1013ug/cm2Induction dose per skin area, one positive responseDermalHumanNTP ICE skin sensitization
1620ug/cm2Induction dose per skin area, one positive responseDermalHumanNTP ICE skin sensitization
4050ug/cm2Induction dose per skin area, one positive responseDermalHumanNTP ICE skin sensitization
3unitlessRelative reliability scoreDermalHumanNTP ICE skin sensitization

Showing 20 of 20 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for Methyl 2-[(3-phenyl-2-propen-1-ylidene)amino]benzoate?

Methyl 2-[(3-phenyl-2-propen-1-ylidene)amino]benzoate has 20 NOAEL studies in the database. The lowest reported value is 1.5 % via Dermal in Human. Source: NTP ICE skin sensitization.

Is Methyl 2-[(3-phenyl-2-propen-1-ylidene)amino]benzoate used in cosmetics?

Yes, Methyl 2-[(3-phenyl-2-propen-1-ylidene)amino]benzoate is also indexed as a cosmetic ingredient under the name Cinnamaldehyde/Methyl Anthranilate Schiff Base. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Methyl 2-[(3-phenyl-2-propen-1-ylidene)amino]benzoate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is Methyl 2-[(3-phenyl-2-propen-1-ylidene)amino]benzoate used outside industrial chemicals?

Methyl 2-[(3-phenyl-2-propen-1-ylidene)amino]benzoate also appears in cosmetics databases.