Is Cinnamaldehyde/Methyl Anthranilate Schiff Base safe in cosmetics?
Cinnamaldehyde/Methyl Anthranilate Schiff Base has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Cinnamaldehyde/Methyl Anthranilate Schiff Base
Also known as: Methyl 2-(cinnamylideneamino)benzoate, EINECS 305-271-1
INCI: CINNAMALDEHYDE/METHYL ANTHRANILATE SCHIFF BASE
Cinnamaldehyde/Methyl Anthranilate Schiff Base (CAS 94386-48-8) is a cosmetic cosmetic ingredient functioning as Fragrance (Parfum). EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 94386-48-8 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (Parfum)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
methyl 2-(cinnamylideneamino)benzoate
InChIKey
OOJFPYZBLJTFST-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted in cosmetics; no specific FDA prohibition
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cinnamaldehyde/Methyl Anthranilate Schiff Base.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
8100 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [792] Kligman AM (1977): Report to RIFM, 29 July and 3 November, unpublished.
HRIPT Human Patch Test Studies
3 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 8100 | - | - |
| HMT | - | 0 | 8100 | - | - |
| HMT | - | 0 | 8100 | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Expert Verdict
Expert safety assessment and concern-level summary for Cinnamaldehyde/Methyl Anthranilate Schiff Base.
Regulatory Flags
potential-allergen
fragrance-component
Known Synonyms
Methyl 2-(cinnamylideneamino)benzoate
EINECS 305-271-1
Chemical Function
Fragrance
Frequently Asked Questions
Is Cinnamaldehyde/Methyl Anthranilate Schiff Base allowed in the EU?
Cinnamaldehyde/Methyl Anthranilate Schiff Base EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cinnamaldehyde/Methyl Anthranilate Schiff Base do in cosmetics?
Cinnamaldehyde/Methyl Anthranilate Schiff Base functions as: Fragrance (Parfum). It is classified as a cosmetic ingredient in our database. CAS number: 94386-48-8.
Is Cinnamaldehyde/Methyl Anthranilate Schiff Base used outside cosmetics?
Cinnamaldehyde/Methyl Anthranilate Schiff Base also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cinnamaldehyde/Methyl Anthranilate Schiff Base compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
CINEOLE
Good
Browse nearby
Skin Protecting
CINNAMAL
Moderate
Browse nearby
Denaturant, Flavouring, Perfuming
CINNAMOMUM CAMPHORA LEAF OIL
Good
Browse nearby
Fragrance
Is Cinnamaldehyde/Methyl Anthranilate Schiff Base in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Cinnamaldehyde/Methyl Anthranilate Schiff Base in your formulation.