What is the GHS hazard classification for 1,2,3-Benzotriazole?
1,2,3-Benzotriazole (CAS 95-14-7) is classified under EU CLP Annex VI as Aquatic Chronic 2. Hazard statements: H411. Source: EU CLP Annex VI (ECHA).
?GHS09
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,2,3-Benzotriazole
Also known as: 1H-Benzotriazole, 4-26-00-00093, 1,2,-Aminozophenylene, Benztriazole, BRN 0112133 (+6 more)
CAS 95-14-7
1,2,3-Benzotriazole (CAS 95-14-7) is a chemical substance; key hazard signal: H411. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
25
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
1,2,3-Benzotriazole
CAS Number
95-14-7
DTXSID
DTXSID6020147
Molecular Formula
C6H5N3
InChI Key
QRUDEWIWKLJBPS-UHFFFAOYSA-N
Monoisotopic Mass
119.048347
Synonyms
1H-Benzotriazole4-26-00-000931,2,-AminozophenyleneBenztriazoleBRN 0112133Cobratec #99EINECS 202-394-1NCI-C03521NSC-3058UNII-86110UXM5YBTA
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Aquatic Chronic 2 | H411 | ?; GHS09 | - |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
34 records
Corrosion inhibitorBiocideAnti-freeze agentPharmaceuticalStabilizing agentPreservativeUV stabilizerDefoamer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 25 of 25 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| - | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =4.2 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 86110UXM5Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 86110UXM5Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 86110UXM5Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 86110UXM5Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.287 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 1.91 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =500 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =560 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =600 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =335 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =335 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1755 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =1755 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1455 | mg/kg bw | LOAEL | - | - | INCHEM_WHO_kemi_kemi_ah2000_24 |
| =1455 | mg/kg bw | LOAEL | - | - | INCHEM_WHO_kemi_kemi_ah2000_24 |
| =1455 | mg/kg bw | LOAEL | - | - | INCHEM_WHO_kemi_kemi_ah2000_24 |
| =1455 | mg/kg bw | LOAEL | - | - | INCHEM_WHO_kemi_kemi_ah2000_24 |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| >- | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| <30 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
| 2350 | ppm | Top dose | - | Mouse | NTP_ICE_cancer |
| 12100 | ppm | Top dose | - | Rat | NTP_ICE_cancer |
| 23500 | ppm | Top dose | - | Mouse | NTP_ICE_cancer |
Showing 25 of 25 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Benzotriazole | 202-394-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BENZOTRIAZOLE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What is the NOAEL for 1,2,3-Benzotriazole?
1,2,3-Benzotriazole has 25 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
What regulatory lists include 1,2,3-Benzotriazole?
1,2,3-Benzotriazole appears on 5 regulatory/inventory lists including Indirect additives food contact (10/2018), active_ingredient; Europe; Pesticides, detected; MN Chemical Screening; surface_water, and 2 more. Source: EPA CPDat.
Is 1,2,3-Benzotriazole used in cosmetics?
Yes, 1,2,3-Benzotriazole is also indexed as a cosmetic ingredient under the name Benzotriazole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,2,3-Benzotriazole come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 1,2,3-Benzotriazole used outside industrial chemicals?
1,2,3-Benzotriazole also appears in cosmetics, pharmaceutical databases.