Is Benzotriazole safe in cosmetics?
Benzotriazole has a safety rating of "POOR" in our database. EU status: restricted. US status: permitted.
Benzotriazole
Also known as: 1H-Benzotriazole, 4-26-00-00093, 1,2,-Aminozophenylene, Benztriazole, BRN 0112133 (+6 more)
INCI: BENZOTRIAZOLE
Benzotriazole (CAS 95-14-7) is a cosmetic cosmetic ingredient functioning as Antimicrobial. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 95-14-7 →
Auto-generated CPSR Part A draft with source citations
Function
Antimicrobial
Safety Rating
POOR
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Not specifically prohibited; not listed as a color additive. No FDA monograph. Permitted by default under FD&C Act unless proven unsafe.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Benzotriazole.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LEL | =335 mg/kg-day | Rat | oral | chronic | ToxRefDB |
| LEL | =335 mg/kg-day | Rat | oral | chronic | ToxRefDB |
| LEL | =1755 mg/kg-day | Mouse | oral | chronic | ToxRefDB |
| LEL | =1755 mg/kg-day | Mouse | oral | chronic | ToxRefDB |
| LOAEL | =335 mg/kg-day | Rat | oral | chronic | ToxRefDB |
| LOAEL | =335 mg/kg-day | Rat | oral | chronic | ToxRefDB |
| LOAEL | =1755 mg/kg-day | Mouse | oral | chronic | ToxRefDB |
| LOAEL | =1755 mg/kg-day | Mouse | oral | chronic | ToxRefDB |
| LC50 | =1.4325 mg/L | Rat | inhalation | - | ChemIDplus |
| LD50 | =500 mg/kg | Guinea Pig | oral | - | ChemIDplus |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Pictograms
?Environmental Hazard
Hazard Class and Category
Aquatic Chronic 2
Hazard Statements
- H411 Toxic to aquatic life with long lasting effects
Inserted via ATP: ATP22
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Suspected
Evidence: Moderate
(2016)
Health effects: Yes
Affected pathways: Thyroid, Estrogenic
Regulatory framework: REACH
Source list: II
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-freeze agent
Biocide
Corrosion inhibitor
Defoamer
Pharmaceutical
Preservative
Stabilizing agent
UV stabilizer
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Benzotriazole.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Benzotriazole by CAS number or substance name.
Studies
6
Lowest NOAEL
36 mg/kg bw/day
Highest NOAEL
120 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
1H-Benzotriazole
4-26-00-00093
1,2,-Aminozophenylene
Benztriazole
BRN 0112133
Cobratec #99
EINECS 202-394-1
NCI-C03521
NSC-3058
UNII-86110UXM5Y
BTA
Chemical Function
Corrosion inhibitor
Biocide
Anti-freeze agent
Pharmaceutical
Stabilizing agent
Preservative
Regulatory Lists
Indirect additives food contact (10/2018)
active_ingredient; Europe; Pesticides
detected; MN Chemical Screening; surface_water
detected; MN Chemical Screening; surface_water
Arts and crafts/Office supplies - home office - pens and markers; detected; Europe
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BENZOTRIAZOLE
ChEMBL ID
CHEMBL84963
Frequently Asked Questions
Is Benzotriazole allowed in the EU?
Benzotriazole EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Benzotriazole do in cosmetics?
Benzotriazole functions as: Antimicrobial. It is classified as a cosmetic ingredient in our database. CAS number: 95-14-7.
Is Benzotriazole used outside cosmetics?
Benzotriazole also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Benzotriazole compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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