Danger GHS06GHS09 NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

2-Methyl-1,4-benzenediamine

Also known as: 4-13-00-00246, BRN 0774521, EINECS 202-442-1, 2-Methyl-para-phenylenediamine, para-Toluenediamine (+7 more)

CAS 95-70-5

2-Methyl-1,4-benzenediamine (CAS 95-70-5) is a chemical substance with GHS signal word Danger; key hazard signal: H332; H312; H301; H317; H411. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, IARC, ECHA REACH.

View cosmetic safety profile for Toluene-2,5-Diamine →

SOURCE NOAEL studies
NOAEL studies
37
SOURCE Chemical inventory jurisdictions
Regulatory lists
4
SOURCE EU CLP Annex VI
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields
Name
2-Methyl-1,4-benzenediamine
CAS Number
95-70-5
Molecular Formula
C7H10N2
InChI Key
OBCSAIDCZQSFQH-UHFFFAOYSA-N
Monoisotopic Mass
122.084398
Synonyms
4-13-00-00246BRN 0774521EINECS 202-442-12-Methyl-para-phenylenediaminepara-Toluenediaminepara-Toluylenediaminepara-Tolylenediaminep-Toluylendiaminep,m-TolylenediamineUNII-24JO8Z0RJU2,5-Toluenediamine2,5-diamino-1-methylbenzene

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 3Not classifiable198716, Sup 7

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 3 *; Skin Sens. 1; Aquatic Chronic 2H332; H312; H301; H317; H411GHS06; GHS09Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records
ListKeywordSource
-Journal of Chemical Engineering & Process TechnologyPublished Articles
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
-Regulatory Toxicology and PharmacologyPublished Articles

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 37 of 37 studies
ValueUnitEndpointRouteSpeciesSource
2.5mg/kg bw/day-oralratRegulatory source
2.5mg/kg-oralratRegulatory source
2.5mg/kg bw/d-oralratRegulatory source
2.5mg/kg bw-oralratRegulatory source
10mg/kg bw/d---Regulatory source
10mg/kg bw/d-oral-Regulatory source
10mg/kg-oralratRegulatory source
10mg/kg bw-oralratRegulatory source
10mg/kg bw/day-oralratRegulatory source
10mg/kg bw/day--ratRegulatory source
50mg/kg bw/d-oralratRegulatory source
50mg/kg bw/d--ratRegulatory source
60mg/kg bw/d---Regulatory source
=0.27mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
0.2%EC3DermalMouseNTP ICE skin sensitization
24JO8Z0RJUUNIIFDA UNII substance identifier--openFDA substances
3IARC groupIARC carcinogenicity classification--IARC Monographs
3unitlessIARC group--NTP ICE cancer
=102mg/kg bwLD50oralRatNTP ICE acute oral
20mg/kg bw/dayLOAELoralratCOSMOS DB
=0.39mg/kg bwNOAELoralratSCCS Opinion
=0.67mg/kgNOAELoralratSCCS Opinion
=0.97mg/kgNOAELoralratSCCS Opinion
=2.5mg/kg bw/dayNOAELoralratSCCS Opinion
=2.5mg/kgNOAELoralratSCCS Opinion
=2.5mg/kg bwNOAELdermalratSCCS Opinion
=2.5mg/kg bw/dNOAELoralratSCCS Opinion
=6.9mg/kg bw/dNOAELoralratSCCS Opinion
10mg/kg bw/dayNOAELoralratCOSMOS DB
=10µg/cmNOAEL-ratSCCS Opinion
=10mg/kg bw/dNOAEL--SCCS Opinion
=10mg/kgNOAELoralratSCCS Opinion
=10mg/kg bw/dayNOAEL-ratSCCS Opinion
=20mg/kg bw/dNOAELoralratSCCS Opinion
=45mg/kgNOAELoralrabbitSCCS Opinion
=45mg/kg bw/dNOAELoralrabbitSCCS Opinion
=45mg/kgNOAELoralratSCCS Opinion

Showing 37 of 37 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registered2-methyl-p-phenylenediamine202-442-1ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/1084/072 October 2007The SCCP is of the opinion that the use of toluene-2,5-diamine cannot be considered safe based on the available data. This conclusion may be re-evaluated if human toxicokinetic data were to become available in which dosages used more closely approximate the intended use of the substance.-Cannot be considered safe on available data. Toluene-2,5-diamine is an extremely potent skin sensitiser. Clarification needed on myocyte degeneration in 90-day study dose-range finding. Substance itself has no mutagenic potential in vivo, but genotoxicity/mutagenicity of finished formulations should be studied.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
2.0%
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the GHS hazard classification for 2-Methyl-1,4-benzenediamine?

2-Methyl-1,4-benzenediamine (CAS 95-70-5) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 3 *; Skin Sens. 1; Aquatic Chronic 2 with signal word Danger. Hazard statements: H332; H312; H301; H317; H411. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2-Methyl-1,4-benzenediamine?

2-Methyl-1,4-benzenediamine has 37 NOAEL studies in the database. The lowest reported value is 0.2 % via Dermal in Mouse. Source: NTP ICE skin sensitization.

What regulatory lists include 2-Methyl-1,4-benzenediamine?

2-Methyl-1,4-benzenediamine appears on 1 regulatory/inventory list including Europe; Personal care - hair coloring. Source: EPA CPDat.

Is 2-Methyl-1,4-benzenediamine a carcinogen according to IARC?

2-Methyl-1,4-benzenediamine is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is 2-Methyl-1,4-benzenediamine used in cosmetics?

Yes, 2-Methyl-1,4-benzenediamine is also indexed as a cosmetic ingredient under the name Toluene-2,5-Diamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Methyl-1,4-benzenediamine come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Methyl-1,4-benzenediamine have different safety status in cosmetics vs industrial chemicals?

2-Methyl-1,4-benzenediamine is classified GHS Danger (H332, H312, H301, H317, H411) in the chemicals database but is restricted in EU cosmetics at max 2.0%.

Is 2-Methyl-1,4-benzenediamine used outside industrial chemicals?

2-Methyl-1,4-benzenediamine also appears in cosmetics databases.