Toluene-2,5-Diamine
INCI: TOLUENE-2,5-DIAMINE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Toluene-2,5-Diamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 10 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 20 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Sensitization Profile
Contact sensitization data for Toluene-2,5-Diamine based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
Expert Verdict
Strong skin sensitizer with extensive cross-reactivity to PPD and p-aminodiphenylamine; must not be used for eyelash/eyebrow dyeing; mandatory allergy warning required; o-toluidine impurity is a Cat 1B carcinogen — must be controlled <50 ppm
Regulatory Flags
Frequently Asked Questions
Is Toluene-2,5-Diamine safe in cosmetics?
Strong skin sensitizer with extensive cross-reactivity to PPD and p-aminodiphenylamine; must not be used for eyelash/eyebrow dyeing; mandatory allergy warning required; o-toluidine impurity is a Cat 1B carcinogen — must be controlled <50 ppm The EU classifies Toluene-2,5-Diamine as "restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Toluene-2,5-Diamine allowed in the EU?
Toluene-2,5-Diamine EU regulatory status: restricted. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does Toluene-2,5-Diamine do in cosmetics?
Toluene-2,5-Diamine functions as: Oxidative hair dye precursor (primary intermediate). It is classified as a cosmetic ingredient in our database. CAS number: 95-70-5.
What is the Margin of Safety for Toluene-2,5-Diamine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Toluene-2,5-Diamine?
The NOAEL (No Observed Adverse Effect Level) for Toluene-2,5-Diamine is 10 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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