NOAEL Data IARC Group 2B Prop 65 REACH Registered Cosmetic Ingredient

2-Amino-4-chlorophenol

Also known as: 4-13-00-00878, BRN 0774859, EINECS 202-458-9, UNII-2Z43LEA3DX

CAS 95-85-2

2-Amino-4-chlorophenol (CAS 95-85-2) is a chemical substance; key hazard signal: IARC Group 2B. Key regulatory status: California Proposition 65, REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, ILO ICSC.

View cosmetic safety profile for 4-Chloro-2-Aminophenol →

Cross-Vertical Regulatory Divergence

2-Amino-4-chlorophenol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H317, H319, H335, H351, H373, H350).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 10 fields

Name

2-Amino-4-chlorophenol

CAS Number

95-85-2

DTXSID

DTXSID5024473

Molecular Formula

C6H6ClNO

InChI Key

SWFNPENEBHAHEB-UHFFFAOYSA-N

Monoisotopic Mass

143.013791

Synonyms

4-13-00-00878BRN 0774859EINECS 202-458-9UNII-2Z43LEA3DX

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 2B	Possibly carcinogenic	2018	123

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records

Chemical	Toxicity Type	Cancer	Developmental	Listed
-	cancer	Yes	No	-

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	WARNING
GHS Hazard Statements	Harmful if swallowed Causes skin irritation May cause an allergic skin reaction Suspected of causing cancer
Short-term Effects	Exposure could cause formation of methaemoglobin. The substance is irritating to the skin.
Long-term Effects	Repeated or prolonged contact may cause skin sensitization. This substance is possibly carcinogenic to humans.
Routes of Exposure	The substance can be absorbed into the body by inhalation and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records

List	Keyword	Source
OEHHA Proposition 65 (1/2023)	California Office of Environmental Health Hazard Assessment	OEHHA Proposition 65 List
banned; Europe; Personal care	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 11 of 11 studies

Value	Unit	Endpoint	Route	Species	Source
LCcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
LCcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
LCcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
2Z43LEA3DX	UNII	FDA UNII substance identifier	-	-	openFDA substances
2Z43LEA3DX	UNII	FDA UNII substance identifier	-	-	openFDA substances
2Z43LEA3DX	UNII	FDA UNII substance identifier	-	-	openFDA substances
2Z43LEA3DX	UNII	FDA UNII substance identifier	-	-	openFDA substances
2B	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2	unitless	IARC group	-	-	NTP_ICE_cancer
=690	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=50	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_HESS

Showing 11 of 11 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2-amino-4-chlorophenol	202-458-9	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL251389

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 2-Amino-4-chlorophenol?

2-Amino-4-chlorophenol has 11 NOAEL studies in the database. The lowest reported value is cancer listing type. Source: California Proposition 65.

What regulatory lists include 2-Amino-4-chlorophenol?

2-Amino-4-chlorophenol appears on 2 regulatory/inventory lists including OEHHA Proposition 65 (1/2023), banned; Europe; Personal care. Source: EPA CPDat.

Is 2-Amino-4-chlorophenol a carcinogen according to IARC?

2-Amino-4-chlorophenol is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2018). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is 2-Amino-4-chlorophenol on the California Proposition 65 list?

Yes, 2-Amino-4-chlorophenol is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.

Is 2-Amino-4-chlorophenol used in cosmetics?

Yes, 2-Amino-4-chlorophenol is also indexed as a cosmetic ingredient under the name 4-Chloro-2-Aminophenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Amino-4-chlorophenol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Amino-4-chlorophenol have different safety status in cosmetics vs industrial chemicals?

2-Amino-4-chlorophenol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H317, H319, H335, H351, H373, H350).

Is 2-Amino-4-chlorophenol used outside industrial chemicals?

2-Amino-4-chlorophenol also appears in cosmetics, pharmaceutical databases.