Poor Cosmetic Ingredient GHS Classified SCCS/CIR Reviewed

4-Chloro-2-Aminophenol

INCI: 4-CHLORO-2-AMINOPHENOL

CAS Number
95-85-2
Function
Hair dyeing (hair colorant)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes CIR Panel found insufficient data to determine safety (2024 reassessment). Coal-tar hair dye exemption technically applies, but CIR could not confirm safety

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
WARNING
Pictograms
excl mark;warn; cancer;health haz
Hazard Statements
Harmful if swallowed Causes skin irritation May cause an allergic skin reaction Suspected of causing cancer
Short-term Exposure Effects
Exposure could cause formation of methaemoglobin. The substance is irritating to the skin.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. This substance is possibly carcinogenic to humans.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir October 6, 2025
Verdict: not safe

he Panel issued an amended report with a revised conclusion stating that 4-Chloro-2-Aminophenol is unsafe for use as a cosmetic ingredient. INTRODUCTION 4-Chloro-2-Aminophenol, which according to the web-based International Cosmetic Ingredient Dictionary and Handbook (Dictionary) is reported to func

Expert Verdict

Prohibited in EU as part of the hair dye ban list. CIR Panel determined insufficient data for safety determination. Not recommended for any EU-market formulations.

⚠️
Concern Level: High

Regulatory Flags

colorant prop65 eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is 4-Chloro-2-Aminophenol safe in cosmetics?

Prohibited in EU as part of the hair dye ban list. CIR Panel determined insufficient data for safety determination. Not recommended for any EU-market formulations. The EU classifies 4-Chloro-2-Aminophenol as "prohibited". Safety rating: POOR. This ingredient has been reviewed by cir.

Is 4-Chloro-2-Aminophenol allowed in the EU?

4-Chloro-2-Aminophenol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does 4-Chloro-2-Aminophenol do in cosmetics?

4-Chloro-2-Aminophenol functions as: Hair dyeing (hair colorant). It is classified as a cosmetic ingredient in our database. CAS number: 95-85-2.

What is the Margin of Safety for 4-Chloro-2-Aminophenol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Is 4-Chloro-2-Aminophenol classified as hazardous under GHS?

4-Chloro-2-Aminophenol carries a GHS signal word of "WARNING". Hazard statements: Harmful if swallowed Causes skin irritation May cause an allergic skin reaction Suspected of causing cancer. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check 4-Chloro-2-Aminophenol compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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