What is the NOAEL for 2,5-Dimethylphenol?
2,5-Dimethylphenol has 8 NOAEL studies in the database. The lowest reported value is 3.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,5-Dimethylphenol
Also known as: 4-06-00-03164, BRN 1099260, 1,4-Dimethyl-2-hydroxybenzene, EINECS 202-461-5, FEMA No. 3595 (+3 more)
CAS 95-87-4
2,5-Dimethylphenol (CAS 95-87-4) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
2,5-Dimethylphenol is classified GHS Danger (H301, H311, H314, H317, H318, H411, H302) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
2,5-Dimethylphenol
CAS Number
95-87-4
DTXSID
DTXSID6025145
Molecular Formula
C8H10O
InChI Key
NKTOLZVEWDHZMU-UHFFFAOYSA-N
Monoisotopic Mass
122.073165
Synonyms
4-06-00-03164BRN 10992601,4-Dimethyl-2-hydroxybenzeneEINECS 202-461-5FEMA No. 35956-Methyl-m-cresol3,6-XylenolUNII-XH3E3564KX
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 33.8 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =3.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| XH3E3564KX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XH3E3564KX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XH3E3564KX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XH3E3564KX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1000 | mM | LOEL | dermal | Mouse | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,5-xylenol | 202-461-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CHEMBL192591
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2,5-Dimethylphenol?
2,5-Dimethylphenol appears on 3 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is 2,5-Dimethylphenol used in cosmetics?
Yes, 2,5-Dimethylphenol is also indexed as a cosmetic ingredient under the name 2,5-XYLENOL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,5-Dimethylphenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 2,5-Dimethylphenol have different safety status in cosmetics vs industrial chemicals?
2,5-Dimethylphenol is classified GHS Danger (H301, H311, H314, H317, H318, H411, H302) in the chemicals database but is allowed in EU cosmetics.
Is 2,5-Dimethylphenol used outside industrial chemicals?
2,5-Dimethylphenol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.