Is 2,5-XYLENOL safe in cosmetics?
2,5-XYLENOL has a safety rating of "GOOD" in our database. EU status: permitted.
GOOD
Cosmetic Ingredient
2,5-XYLENOL
Also known as: 4-06-00-03164, BRN 1099260, 1,4-Dimethyl-2-hydroxybenzene, EINECS 202-461-5, FEMA No. 3595 (+3 more)
2,5-XYLENOL (CAS 95-87-4) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Cross-Vertical Regulatory Divergence
2,5-XYLENOL is classified GHS Danger (H301, H311, H314, H317, H318, H411, H302) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Perfuming
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
2,5-dimethylphenol
InChIKey
NKTOLZVEWDHZMU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 2,5-XYLENOL across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
706
Source: WHO/JECFA
JECFA Evaluation
1-HYDROXY-2,5-DIMETHYLBENZENE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: WHO/JECFA
JECFA Evaluation
2,5-XYLENOL | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for 2,5-XYLENOL — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2,5-XYLENOL by CAS number or substance name.
Studies
6
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ECHA
Known Synonyms
4-06-00-03164
BRN 1099260
1,4-Dimethyl-2-hydroxybenzene
EINECS 202-461-5
FEMA No. 3595
6-Methyl-m-cresol
3,6-Xylenol
UNII-XH3E3564KX
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL192591
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
2,5-XYLENOL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is 2,5-XYLENOL allowed in the EU?
2,5-XYLENOL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,5-XYLENOL do in cosmetics?
2,5-XYLENOL functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 95-87-4.
Is 2,5-XYLENOL used outside cosmetics?
2,5-XYLENOL also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2,5-XYLENOL have different safety status in cosmetics vs industrial chemicals?
2,5-XYLENOL is classified GHS Danger (H301, H311, H314, H317, H318, H411, H302) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check 2,5-XYLENOL compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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