NOAEL Data REACH Registered Cosmetic Ingredient

4-Chlororesorcinol

Also known as: 4-Chlorobenzene-1,3-diol, BRN 2042864, EINECS 202-462-0, UNII-87045U29QJ

CAS 95-88-5

4-Chlororesorcinol (CAS 95-88-5) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 4-Chlororesorcinol →

Cross-Vertical Regulatory Divergence

4-Chlororesorcinol is prohibited in EU cosmetics at max 2.5% but has active industrial GHS classifications (H302, H312, H315, H317, H318, H319, H332, H335).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields

Name

4-Chlororesorcinol

CAS Number

95-88-5

Molecular Formula

C6H5ClO2

InChI Key

JQVAPEJNIZULEK-UHFFFAOYSA-N

Monoisotopic Mass

143.997807

Synonyms

4-Chlorobenzene-1,3-diolBRN 2042864EINECS 202-462-0UNII-87045U29QJ

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 20 of 20 studies

Value	Unit	Endpoint	Route	Species	Source
50	mg/kg bw/d	-	-	human	Regulatory source
200	mg/kg bw/d	-	-	human	Regulatory source
=4.996	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
87045U29QJ	UNII	FDA UNII substance identifier	-	-	openFDA substances
=369	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
100	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
=0.08	mg/kg	NOAEL	oral	rat	SCCS Opinion
=0.106	mg/kg	NOAEL	oral	rat	SCCS Opinion
50	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=50	mg/kg bw/d	NOAEL	-	human	SCCS Opinion
=50	mg/kg/d	NOAEL	oral	rat	SCCS Opinion
=200	mg/kg bw/d	NOAEL	-	human	SCCS Opinion
=210	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=0.08	mg/kg	dermal absorption	oral	rat	Regulatory source
=0.106	mg/kg	dermal absorption	oral	rat	Regulatory source
=50	mg/kg/d	dermal absorption	oral	rat	Regulatory source
210	mg/kg bw/d	genotoxicity	oral	rat	Regulatory source
50	mg/kg bw/d	repeated dose toxicity	oral	rat	Regulatory source
200	mg/kg bw/d	repeated dose toxicity	oral	rat	Regulatory source
210	mg/kg bw/d	repeated dose toxicity	oral	rat	Regulatory source

Showing 20 of 20 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	4-chlororesorcinol	202-462-0	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1391/10	23 March 2010	safe	1.0%	sensitisation potential not excluded
SCCS/1224/09	2010-03-23	Based on the information provided, the SCCS is of the opinion that the use of 4-chlororesorcinol itself as an oxidative hair dye substance at a maximum on-head concentration of 2.5% does not pose a risk to the health of the consumer, apart from its moderate skin sensitising potential.	2.5% on-head	Moderate skin sensitising potential. Genotoxicity/mutagenicity studies in finished hair dye formulations should be undertaken. No carcinogenicity data submitted.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

2.5%

Frequently Asked Questions

What is the NOAEL for 4-Chlororesorcinol?

4-Chlororesorcinol has 20 NOAEL studies in the database. The lowest reported value is 0.08 mg/kg via oral in rat. Source: SCCS Opinion.

What regulatory lists include 4-Chlororesorcinol?

4-Chlororesorcinol appears on 2 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring. Source: EPA CPDat.

Is 4-Chlororesorcinol used in cosmetics?

Yes, 4-Chlororesorcinol is also indexed as a cosmetic ingredient under the name 4-Chlororesorcinol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-Chlororesorcinol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 4-Chlororesorcinol have different safety status in cosmetics vs industrial chemicals?

4-Chlororesorcinol is prohibited in EU cosmetics at max 2.5% but has active industrial GHS classifications (H302, H312, H315, H317, H318, H319, H332, H335).

Is 4-Chlororesorcinol used outside industrial chemicals?

4-Chlororesorcinol also appears in cosmetics databases.