4-Chlororesorcinol
INCI: 4-CHLORORESORCINOL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for 4-Chlororesorcinol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 50 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| LOAEL | 100 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 340 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOEL | 30 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 70 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 70 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 490.48334 mg/kg bw/day | oral | rat | oral | REACH |
Sensitization Profile
Contact sensitization data for 4-Chlororesorcinol based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
Expert Verdict
Moderate sensitizer — mandatory patch test warning. No evidence of carcinogenicity or reproductive/developmental toxicity at 2% dermal. Must not exceed 2.5% after mixing.
Regulatory Flags
Frequently Asked Questions
Is 4-Chlororesorcinol safe in cosmetics?
Moderate sensitizer — mandatory patch test warning. No evidence of carcinogenicity or reproductive/developmental toxicity at 2% dermal. Must not exceed 2.5% after mixing. The EU classifies 4-Chlororesorcinol as "prohibited". Safety rating: MODERATE. 7 toxicological study endpoint(s) are available in our database.
Is 4-Chlororesorcinol allowed in the EU?
4-Chlororesorcinol EU regulatory status: prohibited. Maximum allowed concentration: 2.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-Chlororesorcinol do in cosmetics?
4-Chlororesorcinol functions as: Oxidative hair dyeing (coupler — reacts with primary intermediates to form final dye). It is classified as a cosmetic ingredient in our database. CAS number: 95-88-5.
What is the Margin of Safety for 4-Chlororesorcinol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 4-Chlororesorcinol?
The NOAEL (No Observed Adverse Effect Level) for 4-Chlororesorcinol is 50 mg/kg bw/day based on a Developmental study via oral route in rat. A total of 7 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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