What is the GHS hazard classification for Diethyl oxalate?
Diethyl oxalate (CAS 95-92-1) is classified under EU CLP Annex VI as Acute Tox. 4 *; Eye Irrit. 2 with signal word Warning. Hazard statements: H302; H319. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diethyl oxalate
Also known as: Ethanedioic acid, diethyl ester, 4-02-00-01848, BRN 0606350, EINECS 202-464-1, Oxalic ether (+2 more)
CAS 95-92-1
Diethyl oxalate (CAS 95-92-1) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H319. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Diethyl oxalate is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H319).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
13 fields
Name
Diethyl oxalate
CAS Number
95-92-1
DTXSID
DTXSID2044472
Molecular Formula
C6H10O4
InChI Key
WYACBZDAHNBPPB-UHFFFAOYSA-N
Monoisotopic Mass
146.057909
Synonyms
Ethanedioic acid, diethyl ester4-02-00-01848BRN 0606350EINECS 202-464-1Oxalic etherDiethylester kyseliny staveloveUNII-860M3ZWF6J
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Eye Irrit. 2 | H302; H319 | GHS07 | Warning |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
7 records
SolventPlasticizerDeodorizerChelating agentSoftener and conditionerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 860M3ZWF6J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 860M3ZWF6J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 860M3ZWF6J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 860M3ZWF6J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diethyl oxalate | 202-464-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CHEMBL3183226
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Diethyl oxalate?
Diethyl oxalate has 5 NOAEL studies in the database. The lowest reported value is 0.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
What regulatory lists include Diethyl oxalate?
Diethyl oxalate appears on 3 regulatory/inventory lists including CEDI, Indirect additives food contact (10/2018), Europe. Source: EPA CPDat.
Is Diethyl oxalate used in cosmetics?
Yes, Diethyl oxalate is also indexed as a cosmetic ingredient under the name Diethyl Oxalate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diethyl oxalate come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Diethyl oxalate have different safety status in cosmetics vs industrial chemicals?
Diethyl oxalate is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H319).
Is Diethyl oxalate used outside industrial chemicals?
Diethyl oxalate also appears in cosmetics, pharmaceutical, cannabis databases.