Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Diethyl Oxalate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | ca.63 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 20 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.63 mg/kg bw/day | oral | - | oral | REACH |
Expert Verdict
Reproductive toxicant Category 1B (may damage fertility and unborn child); skin corrosive Category 1A/1B; STOT-RE Category 1-2 (kidney) upon repeated oral exposure; acute oral toxicity Category 4.
Frequently Asked Questions
Is Diethyl Oxalate safe in cosmetics?
Reproductive toxicant Category 1B (may damage fertility and unborn child); skin corrosive Category 1A/1B; STOT-RE Category 1-2 (kidney) upon repeated oral exposure; acute oral toxicity Category 4. The EU classifies Diethyl Oxalate as "prohibited". Safety rating: POOR. 3 toxicological study endpoint(s) are available in our database.
Is Diethyl Oxalate allowed in the EU?
Diethyl Oxalate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethyl Oxalate do in cosmetics?
Diethyl Oxalate functions as: Solvent / synthesis intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 95-92-1.
What is the Margin of Safety for Diethyl Oxalate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diethyl Oxalate?
The NOAEL (No Observed Adverse Effect Level) for Diethyl Oxalate is ca.63 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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