Is Diethyl Oxalate safe in cosmetics?
Diethyl Oxalate has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Poor
Cosmetic Ingredient
Diethyl Oxalate
Also known as: Ethanedioic acid, diethyl ester, 4-02-00-01848, BRN 0606350, EINECS 202-464-1, Oxalic ether (+2 more)
INCI: DIETHYL OXALATE
Diethyl Oxalate (CAS 95-92-1) is a cosmetic cosmetic ingredient functioning as Solvent / synthesis intermediate. NOAEL 20 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 95-92-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Diethyl Oxalate is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H314, H319, H373, H227, H315).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Solvent / synthesis intermediate
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
diethyl oxalate
InChIKey
WYACBZDAHNBPPB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted (no specific CFR prohibition), but CMR profile makes inclusion indefensible in a CPSR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diethyl Oxalate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diethyl Oxalate across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Acute Tox. 4 *; Eye Irrit. 2
Hazard Statements
- H302 Harmful if swallowed
- H319 Causes serious eye irritation
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
STRONG IRRITANT TO SKIN AND MUCOUS MEMBRANES.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Deodorizer
Flavouring and nutrient
Plasticizer
Softener and conditioner
Solvent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Diethyl Oxalate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Diethyl Oxalate by CAS number or substance name.
Studies
6
Lowest NOAEL
20 mg/kg bw/day
Highest NOAEL
30 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Ethanedioic acid, diethyl ester
4-02-00-01848
BRN 0606350
EINECS 202-464-1
Oxalic ether
Diethylester kyseliny stavelove
UNII-860M3ZWF6J
Chemical Function
Solvent
Plasticizer
Deodorizer
Chelating agent
Softener and conditioner
Flavouring and nutrient
Regulatory Lists
CEDI
Indirect additives food contact (10/2018)
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183226
Frequently Asked Questions
Is Diethyl Oxalate allowed in the EU?
Diethyl Oxalate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethyl Oxalate do in cosmetics?
Diethyl Oxalate functions as: Solvent / synthesis intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 95-92-1.
Is Diethyl Oxalate used outside cosmetics?
Diethyl Oxalate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Diethyl Oxalate have different safety status in cosmetics vs industrial chemicals?
Diethyl Oxalate is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H314, H319, H373, H227, H315).
Compliance Tools
Check Diethyl Oxalate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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