What is the NOAEL for Dihydroxyacetone?
Dihydroxyacetone has 7 NOAEL studies in the database. The lowest reported value is 16.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dihydroxyacetone
Also known as: 1,3-Dihydroxypropan-2-one, 4-01-00-04119, BRN 1740268, 1,3-Dihydroxypropanone, EINECS 202-494-5 (+3 more)
CAS 96-26-4
Dihydroxyacetone (CAS 96-26-4) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Dihydroxyacetone
CAS Number
96-26-4
DTXSID
DTXSID0025072
Molecular Formula
C3H6O3
InChI Key
UOQFZGVGGMHGEE-UHFFFAOYSA-N
Monoisotopic Mass
90.031694
Synonyms
1,3-Dihydroxypropan-2-one4-01-00-04119BRN 17402681,3-DihydroxypropanoneEINECS 202-494-5NSC-24343UNII-O10DDW6JOOVitadye
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
16 records
Softener and conditionerReducing agentDyeFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =16.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| O10DDW6JOO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O10DDW6JOO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O10DDW6JOO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O10DDW6JOO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >16000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,3-dihydroxyacetone | 202-494-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
2 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1612/19 | 03-04 March 2020 | safe | 6.25% | none noted |
| SCCS/1422/10 | 14 December 2010 | safe with restrictions | Various (self-tanning agent) | Reactive carbonyl compound; potential inhalation exposure from sprays; skin safety acceptable at cosmetic use levels |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
10% self-tanning; 6.25% non-oxidative hair dye (leave-on)
Category
Humectants
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DIHYDROXYACETONE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Dihydroxyacetone?
Dihydroxyacetone appears on 4 regulatory/inventory lists including pharmaceutical, Personal care, Canada; pharmaceutical, and 1 more. Source: EPA CPDat.
Is Dihydroxyacetone used in cosmetics?
Yes, Dihydroxyacetone is also indexed as a cosmetic ingredient under the name Dihydroxyacetone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dihydroxyacetone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Dihydroxyacetone used outside industrial chemicals?
Dihydroxyacetone also appears in cosmetics, pharmaceutical, food safety databases.