Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Dihydroxyacetone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | >1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
DHA is EU-restricted (Annex III, Entry 322) with a well-established SCCS safety profile confirming safety up to 10% in self-tanning and 6.25% in leave-on hair dye within its aggregate MoS >100. Non-sensitizing per LLNA with very low systemic absorption confirmed in vivo.
Regulatory Flags
Frequently Asked Questions
Is Dihydroxyacetone safe in cosmetics?
DHA is EU-restricted (Annex III, Entry 322) with a well-established SCCS safety profile confirming safety up to 10% in self-tanning and 6.25% in leave-on hair dye within its aggregate MoS >100. Non-sensitizing per LLNA with very low systemic absorption confirmed in vivo. The EU classifies Dihydroxyacetone as "restricted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.
Is Dihydroxyacetone allowed in the EU?
Dihydroxyacetone EU regulatory status: restricted. Maximum allowed concentration: 10% self-tanning; 6.25% non-oxidative hair dye (leave-on). This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydroxyacetone do in cosmetics?
Dihydroxyacetone functions as: Skin Tanning, Skin Conditioning, Hair Colouring. It is classified as a cosmetic ingredient in our database. CAS number: 96-26-4.
What is the Margin of Safety for Dihydroxyacetone?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dihydroxyacetone?
The NOAEL (No Observed Adverse Effect Level) for Dihydroxyacetone is 1000 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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