What is the NOAEL for 1,3-Dioxolan-2-one?
1,3-Dioxolan-2-one has 8 NOAEL studies in the database. The lowest reported value is 15 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,3-Dioxolan-2-one
Also known as: Ethylene carbonate, 1,3-Dioxacyclopentan-2-one, Dioxolone-2, EINECS 202-510-0, Ethylene carbonic acid (+3 more)
CAS 96-49-1
1,3-Dioxolan-2-one (CAS 96-49-1) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
1,3-Dioxolan-2-one
CAS Number
96-49-1
DTXSID
DTXSID2026600
Molecular Formula
C3H4O3
InChI Key
KMTRUDSVKNLOMY-UHFFFAOYSA-N
Monoisotopic Mass
88.016044
Synonyms
Ethylene carbonate1,3-Dioxacyclopentan-2-oneDioxolone-2EINECS 202-510-0Ethylene carbonic acidEthylene glycol, cyclic carbonateEthylenester kyseliny uhliciteUNII-RGJ96TB7R7
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Solvent
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =15 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| RGJ96TB7R7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RGJ96TB7R7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RGJ96TB7R7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RGJ96TB7R7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =10000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =750 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| =1500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ethylene carbonate | 202-510-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3181803
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
Is 1,3-Dioxolan-2-one used in cosmetics?
Yes, 1,3-Dioxolan-2-one is also indexed as a cosmetic ingredient under the name Ethylene Carbonate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,3-Dioxolan-2-one come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 1,3-Dioxolan-2-one used outside industrial chemicals?
1,3-Dioxolan-2-one also appears in cosmetics, pharmaceutical, cannabis databases.