Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Ethylene Carbonate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 25000 other | oral | rat | oral | REACH |
| LOAEL | 30000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 150 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1108 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 554 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 150 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | 1108 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | 554 mg/kg bw/day | oral | - | oral | REACH |
Expert Verdict
Classified as irritant to eyes and skin; hydrolysis yields ethylene glycol and CO₂ — ethylene glycol metabolite (oxalic acid) presents systemic toxicity concern at high doses; not appropriate for leave-on products at high concentrations; verify pH stability in formulation
Frequently Asked Questions
Is Ethylene Carbonate safe in cosmetics?
Classified as irritant to eyes and skin; hydrolysis yields ethylene glycol and CO₂ — ethylene glycol metabolite (oxalic acid) presents systemic toxicity concern at high doses; not appropriate for leave-on products at high concentrations; verify pH stability in formulation The EU classifies Ethylene Carbonate as "restricted". Safety rating: MODERATE. 8 toxicological study endpoint(s) are available in our database.
Is Ethylene Carbonate allowed in the EU?
Ethylene Carbonate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethylene Carbonate do in cosmetics?
Ethylene Carbonate functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 96-49-1.
What is the Margin of Safety for Ethylene Carbonate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ethylene Carbonate?
The NOAEL (No Observed Adverse Effect Level) for Ethylene Carbonate is 25000 other based on a oral study via oral route in rat. A total of 8 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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