What is the NOAEL for Eugenol?
Eugenol has 70 NOAEL studies in the database. The lowest reported value is 1 mg/kg bw/day in Consumers. Source: EFSA.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Eugenol
Also known as: 4-Allylcatechol 2-methyl ether, 5-Allylguaiacol, BRN 1366759, Caswell No. 456BC, EINECS 202-589-1 (+15 more)
CAS 97-53-0
Eugenol (CAS 97-53-0) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
70
SOURCE
Chemical inventory jurisdictions
Regulatory lists
60
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Eugenol
CAS Number
97-53-0
Molecular Formula
C10H12O2
InChI Key
RRAFCDWBNXTKKO-UHFFFAOYSA-N
Monoisotopic Mass
164.08373
Synonyms
4-Allylcatechol 2-methyl ether5-AllylguaiacolBRN 1366759Caswell No. 456BCEINECS 202-589-1EPA Pesticide Chemical Code 1027011,3,4-EugenolFEMA No. 2467FEMA Number 2467NCI-C50453Synthetic eugenol2-Metoksy-4-allilofenol
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 36, Sup 7 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceHumectant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| Europe | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - dental care - toothpaste | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; detected; Europe; Personal care - body hygiene - body wash; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - dishwasher and dishes; Cleaning products and household care - general household cleaning - surface cleaner; Cleaning products and household care - laundry and fabric treatment; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 70 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| <=2.5 | mg/kg | ADI | oral | Human | WHO/JECFA |
| =2.5 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| 53.4 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 72.3 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 90 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 108.8 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 112.2 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 117.7 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 125.2 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 137.2 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 169.4 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 265.2 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 5.698 | ug/mL | CD86, EC120 | Dermal | - | NTP ICE skin sensitization |
| 25 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 29.36 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 53.1 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 64.4 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 77 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 136.3 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 154.9 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 157.5 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 163.8 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 204.8 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 141.6 | ug/mL | CV70 | Dermal | - | NTP ICE skin sensitization |
| 95.8 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 140.2 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 143.2 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 147 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 150 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 234 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 320 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 103.6 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 14.6 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 4 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =21.2 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 9.2 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 32.1 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 38.3 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 4.2 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 10.2 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 19.2 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 14.2 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 21 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 21.25 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 64 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 197.5 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 229.6 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 231.2 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 236 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
Showing 50 of 70 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Eugenol | 202-589-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
10 ppm in leave-on products, 100 ppm in rinse-off products
Category
fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
EUGENOL
ChEMBL Phase
0.5
Adverse Events
0
Bioactivity
10
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: 2.5 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Eugenol?
Eugenol appears on 24 regulatory/inventory lists including Europe, active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, and 21 more. Source: EPA CPDat.
Is Eugenol a carcinogen according to IARC?
Eugenol is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Eugenol used in cosmetics?
Yes, Eugenol is also indexed as a cosmetic ingredient under the name Eugenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Eugenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Eugenol used outside industrial chemicals?
Eugenol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.