Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Eugenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 638 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 1200 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1400 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 410.5 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 25 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
Sensitization Profile
Contact sensitization data for Eugenol based on clinical patch test studies and IFRA standards.
Source: ESSCA/IVDK
Dermal Penetration Profile
Skin absorption and penetration characteristics of Eugenol, relevant to systemic exposure and MoS calculations.
Source: SCCS/1459/11, IFRA
Expert Verdict
EU 26 declared allergen with moderate sensitization rates. Occurs naturally in clove and cinnamon oils; EU regulations and IFRA standards apply equally to natural and synthetic origin. Must be individually declared on EU labels above threshold concentrations.
Regulatory Flags
Frequently Asked Questions
Is Eugenol safe in cosmetics?
EU 26 declared allergen with moderate sensitization rates. Occurs naturally in clove and cinnamon oils; EU regulations and IFRA standards apply equally to natural and synthetic origin. Must be individually declared on EU labels above threshold concentrations. The EU classifies Eugenol as "restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Eugenol allowed in the EU?
Eugenol EU regulatory status: restricted. Maximum allowed concentration: 10 ppm in leave-on products, 100 ppm in rinse-off products. This is based on EU Regulation 1223/2009 and its amendments.
What does Eugenol do in cosmetics?
Eugenol functions as: fragrance; antimicrobial; anesthetic. It is classified as a Fragrance in our database. CAS number: 97-53-0.
What is the Margin of Safety for Eugenol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Eugenol?
The NOAEL (No Observed Adverse Effect Level) for Eugenol is 638 mg/kg bw/day based on a Carcinogenicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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